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dc.contributor.authorOlea Serrano, Nicolás 
dc.contributor.authorPulgar Encinas, Rosa María 
dc.contributor.authorPérez, Pilar
dc.contributor.authorOlea Serrano, Fátima 
dc.contributor.authorRivas, A.
dc.contributor.authorNovillo-Fertrell, Arancha
dc.contributor.authorPedraza Muriel, Vicente
dc.contributor.authorSoto, Ana M.
dc.contributor.authorSonnenschein, Carlos
dc.identifier.citationOlea, N.; et al. Estrogenicity of resin-based composites and sealants used in dentistry. Environmental Health Perspectives, 104(3): 298-305 (1996). []es_ES
dc.description.abstractWe tested some resin-based composites used in dentistry for their estrogenic activity. A sealant based on bisphenol-A diglycidylether methacrylate (bis-GMA) increased cell yields, progesterone receptor expression, and pS2 secretion in human estrogen-target, serum-sensitive MCF7 breast cancer cells. Estrogenicity was due to bisphenol-A and bisphenol-A dimethacrylate, monomers found in the base paste of the dental sealant and identified by mass spectrometry. Samples of saliva from 18 subjects treated with 50 mg of a bis-GMA-based sealant applied on their molars were collected 1 hr before and after treatment. Bisphenol-A (range 90-931 micrograms) was identified only in saliva collected during a 1-hr period after treatment. The use of bis-GMA-based resins in dentistry, and particularly the use of sealants in children, appears to contribute to human exposure to xenoestrogens.es_ES
dc.description.sponsorshipThis work was supported by grant 94/1551 from the Fondo de Investigaciones Sanitarias (FIS), the Spanish Ministry of Health and the Consejeria de Salud, Junta de Andalucía (to N.O.), National Institutes of Health grant CA13410 (to C.S.), CA55574, and NSF-DCB-105594 (to A.M.S.).es_ES
dc.publisherNational Institute of Environmental Healthes_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.subjectComposite resins and sealantses_ES
dc.subjectE-screen bioassayes_ES
dc.subjectRestorative dentistryes_ES
dc.titleEstrogenicity of resin-based composites and sealants used in dentistryes_ES

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