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dc.contributor.authorGonzález-Delgado, José A.
dc.contributor.authorEscobar, Gustavo
dc.contributor.authorArteaga, Jesús F.
dc.contributor.authorFernández Barrero, Alejandro 
dc.date.accessioned2014-05-29T13:18:12Z
dc.date.available2014-05-29T13:18:12Z
dc.date.issued2014
dc.identifier.citationGonzález-Delgado, J.A.; et al. Easy Access to a Cyclic Key Intermediate for the Synthesis of Trisporic Acids and Related Compounds. Molecules, 19(2): 1748-1762 (2014). [http://hdl.handle.net/10481/32032]es_ES
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10481/32032
dc.description.abstractThe synthesis of a cyclohexane skeleton possessing different oxygenated functional groups at C–3, C–8 and C–9, and a D1,6-double bond has been accomplished in 10 steps with an overall 17% yield. This compound is a key intermediate for access to a wide range of compounds of the bioactive trisporoid family. The synthetic sequence consists of the preparation of a properly functionalized epoxygeraniol derivative, and its subsequent stereoselective cyclization mediated by Ti(III). This last step implies a domino process that starts with a homolytic epoxide opening followed by a radical cyclization and regioselective elimination. This concerted process gives access to the cyclohexane moiety with stereochemical control of five of its six carbon atoms.es_ES
dc.description.sponsorshipThis project was supported by the Spanish Ministry of Economy and Competitiveness (project CTQ2010-16818-BQ).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es_ES
dc.subjectTrisporiodses_ES
dc.subjectApocarotenoides_ES
dc.subjectDomino reactiones_ES
dc.subjectStereoselective synthesises_ES
dc.titleEasy Access to a Cyclic Key Intermediate for the Synthesis of Trisporic Acids and Related Compoundses_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.3390/molecules19021748


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