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Genomic profile of trinitrobencenesulfonic acid (TNBS)-induced colitis model (GSE9293)

dc.contributor.authorSánchez De Medina López-Huertas, Fermín 
dc.contributor.authorMartínez Augustín, María Olga 
dc.contributor.authorMontero Meléndez, Trinidad
dc.contributor.authorSuárez García, Antonio
dc.contributor.authorZarzuelo Zurita, Antonio 
dc.contributor.authorSuárez, María Dolores
dc.contributor.authorLlor, Xavier
dc.contributor.authorVieites Fernández, José M.
dc.contributor.authorGassull, Miguel
dc.date.accessioned2014-05-13T08:19:33Z
dc.date.available2014-05-13T08:19:33Z
dc.date.issued2008-11-01
dc.identifier.otherGEO accession: GSE9293
dc.identifier.urihttp://hdl.handle.net/10481/31655
dc.description[Organism] Rattus norvegicuses_ES
dc.description[Experiment type] Expression profiling by arrayes_ES
dc.description[Overall design] A single enema of 10mg of TNBS in 50% ethanol was administered to rats at day 0. Samples were recovered at days 2, 5, 7 and 14. According to inflammatory markers (myeloperoxidase activity, body weigh loss, colonic weigh/length ratio) we selected three replicates at each time point for the genimoc analysis, and 6 healthy control rats that received a saline enema. RNA was extracted from homogenized full-thickness colonic tissues in Trizol® reagent (Invitrogen) and purified with RNeasy affinity columns (Qiagen), according to manufacturer´s protocol. The microarray analysis was performed by Progenika Biopharma (Bilbao, Spain) on GeneChip® Rat Genome 230 2.0 Array (Affymetrix). All sample labeling (biotin), hybridization, staining and scanning procedures were carried out using Affimetrix, standard protocols (www.affymetrix.com). Normalization was carried out using Bioconductor sofware (affyPLM package).es_ES
dc.description[Platforms] GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Arrayes_ES
dc.description[Relations] BioProject PRJNA102933es_ES
dc.description1. GSM235052 Healthy control, replicate 1. [Characteristics] Sprague-Dawley female rats Tissue: full-thickness colon Rat received wateres_ES
dc.description2. GSM235053 Healthy control, replicate 2. Characteristics Sprague-Dawley female rats Tissue:full-thickness colon Rat received wateres_ES
dc.description3. GSM235055 Helathy control, replicate 3. [Characteristics] Sprague-Dawley female rats Tissue: full-thickness colon Rat received wateres_ES
dc.description4.GSM235056 Healthy control, replicate 4. [Characteristics] Sprague-Dawley female rats Tissue: full-thickness colon Rat received wateres_ES
dc.description5. GSM235057 Healthy control, replicate 5. [Characteristics] Sprague-Dawley female rats Tissue: full-thickness colon Rat received wateres_ES
dc.description6. GSM235058 Healthy control, replicate 6. [Characteristics] Sprague-Dawley female rats Tissue: full-thickness colon Rat received wateres_ES
dc.description7. GSM235552 TNBS day 2, replicate 1. [Characteristics] Sprague-Dawley female rat Tissue: full-thickness colon Rat received an enema of 10mg TNBS in 50% ethanol at day 0es_ES
dc.description8. GSM235558 TNBS day 2, replicate 2. [Characteristics] Sprague-Dawley female rat Tissue: full-thickness colon Rat received an enema of 10mg TNBS in 50% ethanol at day 0es_ES
dc.description9. GSM235559 TNBS day 2, replicate 3. [Characteristics] Sprague-Dawley female rat Tissue: full-thickness colon Rat received an enema of 10mg TNBS in 50% ethanol at day 0es_ES
dc.description10. GSM235643 TNBS day 5, replicate 1. [Characteristics] Sprague-Dawley female rat Tissue: full-thickness colon Rat received an enema of 10mg TNBS in 50% ethanol at day 0es_ES
dc.description11. GSM235745 TNBS day 5, replicate 2. [Characteristics] Sprague-Dawley female rat Tissue: full-thickness colon Rat received an enema of 10mg TNBS in 50% ethanol at day 0es_ES
dc.description12. GSM235832 TNBS day 5, replicate 3. [Characteristics] Sprague-Dawley female rat Tissue: full-thickness colon Rat received an enema of 10mg TNBS in 50% ethanol at day 0es_ES
dc.description13. GSM235872 TNBS day 7, replicate 1. [Characteristics] Sprague-Dawley female rat Tissue: full-thickness colon Rat received an enema of 10mg TNBS in 50% ethanol at day 0es_ES
dc.description14. GSM235873 TNBS day 7, replicate 2. [Characteristics] Sprague-Dawley female rat Tissue: full-thickness colon Rat received an enema of 10mg TNBS in 50% ethanol at day 0es_ES
dc.description15. GSM236126 TNBS day 7, replicate 3.[Characteristics] Sprague-Dawley female rat Tissue: full-thickness colon Rat received an enema of 10mg TNBS in 50% ethanol at day 0es_ES
dc.description16. GSM236922 TNBS day 14, replicate 1. [Characteristics] Sprague-Dawley female rat Tissue: full-thickness colon Rat received an enema of 10mg TNBS in 50% ethanol at day 0es_ES
dc.description17. GSM236924 TNBS day 14, replicate 2. [Characteristics] Sprague-Dawley female rat Tissue: full-thickness colon Rat received an enema of 10mg TNBS in 50% ethanol at day 0es_ES
dc.description18. GSM236925 TNBS day 14, replicate 3. [Characteristics] Sprague-Dawley female rat Tissue: full-thickness colon Rat received an enema of 10mg TNBS in 50% ethanol at day 0es_ES
dc.description.abstractTrinitrobenzenesulfonic acid (TNBS) rat colitis is one of the most widely used models of inflammatory bowel disease, a condition whose etiology and pathophysiology are incompletely understood. We have characterized the model at the genomic level following a longitudinal approach.es_ES
dc.language.isoenges_ES
dc.publisherUniversidad de Granadaes_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 License
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectDataseten_US
dc.subjectAnimals es_ES
dc.subjectChordateses_ES
dc.subjectMammals es_ES
dc.subjectNonhuman vertebrateses_ES
dc.subjectRodents es_ES
dc.subjectMuridae es_ES
dc.subjectRattus norvegicuses_ES
dc.titleGenomic profile of trinitrobencenesulfonic acid (TNBS)-induced colitis model (GSE9293)es_ES
dc.typedatasetes_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.30827/Digibug.31655
dc.publication.year2008es_ES


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