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dc.contributor.authorCuyás, Elisabet
dc.contributor.authorVerdejo García, Antonio Javier 
dc.contributor.authorFagundo, Ana Beatriz
dc.contributor.authorKhymenets, Olha
dc.contributor.authorRodríguez, Joan
dc.contributor.authorCuenca, Aida
dc.contributor.authorSola Llopis, Susana de
dc.contributor.authorLangohr, Klaus
dc.contributor.authorPeña-Casanova, Jordi
dc.contributor.authorTorrens, Marta
dc.contributor.authorMartín-Santos, Rocío
dc.contributor.authorFarré, Magí
dc.contributor.authorTorre, Rafael de la
dc.identifier.citationCuyás, E.; et al. The Influence of Genetic and Environmental Factors among MDMA Users in Cognitive Performance. Plos One, 6(11): e27206 (2011). []es_ES
dc.identifier.otherdoi: 10.1371/journal.pone.0027206
dc.description.abstractThis study is aimed to clarify the association between MDMA cumulative use and cognitive dysfunction, and the potential role of candidate genetic polymorphisms in explaining individual differences in the cognitive effects of MDMA. Gene polymorphisms related to reduced serotonin function, poor competency of executive control and memory consolidation systems, and high enzymatic activity linked to bioactivation of MDMA to neurotoxic metabolites may contribute to explain variations in the cognitive impact of MDMA across regular users of this drug. Sixty ecstasy polydrug users, 110 cannabis users and 93 non-drug users were assessed using cognitive measures of Verbal Memory (California Verbal Learning Test, CVLT), Visual Memory (Rey-Osterrieth Complex Figure Test, ROCFT), Semantic Fluency, and Perceptual Attention (Symbol Digit Modalities Test, SDMT). Participants were also genotyped for polymorphisms within the 5HTT, 5HTR2A, COMT, CYP2D6, BDNF, and GRIN2B genes using polymerase chain reaction and TaqMan polymerase assays. Lifetime cumulative MDMA use was significantly associated with poorer performance on visuospatial memory and perceptual attention. Heavy MDMA users (>100 tablets lifetime use) interacted with candidate gene polymorphisms in explaining individual differences in cognitive performance between MDMA users and controls. MDMA users carrying COMT val/val and SERT s/s had poorer performance than paired controls on visuospatial attention and memory, and MDMA users with CYP2D6 ultra-rapid metabolizers performed worse than controls on semantic fluency. Both MDMA lifetime use and gene-related individual differences influence cognitive dysfunction in ecstasy users.es_ES
dc.description.sponsorshipThis study was supported by grants from the National Institutes of Health (NIH) grant no. 1 R01 DA017987, Grant 2005SGR00032, Fondo de Investigaciones Sanitarias (FIS-00/00777), Plan Nacional Sobre Drogas (INT/2012/2002) Spain, Plan Nacional Sobre Drogas: PNSD 2006/101(2007–2009) Spain.es_ES
dc.publisherPublic Library of Science (PLOS)es_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.subjectAttention es_ES
dc.subjectCannabis es_ES
dc.subjectCognitive psychologyes_ES
dc.subjectDrug interactions es_ES
dc.subjectMemory es_ES
dc.subjectNeuropsychology es_ES
dc.subjectVariant genotypeses_ES
dc.titleThe Influence of Genetic and Environmental Factors among MDMA Users in Cognitive Performancees_ES

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