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dc.contributor.authorGalindo Gallardo, Pilar
dc.contributor.authorRodríguez Gómez, Isabel María 
dc.contributor.authorGonzález-Manzano, Susana
dc.contributor.authorDueñas, Montserrat
dc.contributor.authorJiménez Moleón, Rosario 
dc.contributor.authorMenéndez, Carmen
dc.contributor.authorVargas, Félix
dc.contributor.authorTamargo, Juan
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorPérez-Vizcaíno, Francisco
dc.contributor.authorDuarte Pérez, Juan Manuel 
dc.date.accessioned2014-03-24T09:45:37Z
dc.date.available2014-03-24T09:45:37Z
dc.date.issued2012
dc.identifier.citationGalindo, P.; et al. Glucuronidated Quercetin Lowers Blood Pressure in Spontaneously Hypertensive Rats via Deconjugation. Plos One, 7(3): e32673 (2012). [doi: 10.1371/journal.pone.0032673]es_ES
dc.identifier.issn1932-6203
dc.identifier.otherdoi: 10.1371/journal.pone.0032673
dc.identifier.urihttp://hdl.handle.net/10481/31055
dc.description.abstract[Background] Chronic oral quercetin reduces blood pressure and restores endothelial dysfunction in hypertensive animals. However, quercetin (aglycone) is usually not present in plasma, because it is rapidly metabolized into conjugated, mostly inactive, metabolites. The aim of the study is to analyze whether deconjugation of these metabolites is involved in the blood pressure lowering effect of quercetin. [Methodology/Principal Findings] We have analyzed the effects on blood pressure and vascular function in vitro of the conjugated metabolites of quercetin (quercetin-3-glucuronide, Q3GA; isorhamnetin-3-glucuronide, I3GA; and quercetin-3′-sulfate, Q3'S) in spontaneously hypertensive rats (SHR). Q3GA and I3GA (1 mg/kg i.v.), but not Q3'S, progressively reduced mean blood pressure (MBP), measured in conscious SHR. The hypotensive effect of Q3GA was abolished in SHR treated with the specific inhibitor of β-glucuronidase, saccharic acid 1,4-lactone (SAL, 10 mg/ml). In mesenteric arteries, unlike quercetin, Q3GA had no inhibitory effect in the contractile response to phenylephrine after 30 min of incubation. However, after 1 hour of incubation Q3GA strongly reduced this contractile response and this effect was prevented by SAL. Oral administration of quercetin (10 mg/Kg) induced a progressive decrease in MBP, which was also suppressed by SAL. [Conclusions] Conjugated metabolites are involved in the in vivo antihypertensive effect of quercetin, acting as molecules for the plasmatic transport of quercetin to the target tissues. Quercetin released from its glucuronidated metabolites could be responsible for its vasorelaxant and hypotensive effect.es_ES
dc.description.sponsorshipThis work was supported by Grants from the Spanish Ministerio de Ciencia e Innovación (AGL2007-66108, SAF2008-03948, AGL2009-12001 and SAF2010-22066) and Consolider-Ingenio 2010 Programme (CSD2007-00063), Junta de Andalucia (Proyecto de Excelencia P06-CTS-01555), and Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III (Red HERACLES RD06/0009 and Red de Investigación Renal, REDinREN RD06/0016/0017).es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Science (PLOS)es_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es_ES
dc.subjectAntihypertensiveses_ES
dc.subjectBlood plasma es_ES
dc.subjectBlood pressurees_ES
dc.subjectDrug metabolismes_ES
dc.subjectHeart ratees_ES
dc.subjectHypertension es_ES
dc.subjectMesenteric arterieses_ES
dc.subjectMethylationes_ES
dc.titleGlucuronidated Quercetin Lowers Blood Pressure in Spontaneously Hypertensive Rats via Deconjugationes_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1371/journal.pone.0032673


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