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dc.contributor.authorMejias, Jorge F.
dc.contributor.authorKappen, Hilbert J.
dc.contributor.authorTorres Agudo, Joaquín J.
dc.date.accessioned2014-03-21T13:50:06Z
dc.date.available2014-03-21T13:50:06Z
dc.date.issued2007
dc.identifier.citationMejias, J.F.; Kappen, H.J.; Torres, J.J. Irregular Dynamics in Up and Down Cortical States. Plos One, 5(11): e13651 (2010). [http://hdl.handle.net/10481/31034]es_ES
dc.identifier.issn1932-6203
dc.identifier.otherdoi: 10.1371/journal.pone.0013651
dc.identifier.urihttp://hdl.handle.net/10481/31034
dc.description.abstractComplex coherent dynamics is present in a wide variety of neural systems. A typical example is the voltage transitions between up and down states observed in cortical areas in the brain. In this work, we study this phenomenon via a biologically motivated stochastic model of up and down transitions. The model is constituted by a simple bistable rate dynamics, where the synaptic current is modulated by short-term synaptic processes which introduce stochasticity and temporal correlations. A complete analysis of our model, both with mean-field approaches and numerical simulations, shows the appearance of complex transitions between high (up) and low (down) neural activity states, driven by the synaptic noise, with permanence times in the up state distributed according to a power-law. We show that the experimentally observed large fluctuation in up and down permanence times can be explained as the result of sufficiently noisy dynamical synapses with sufficiently large recovery times. Static synapses cannot account for this behavior, nor can dynamical synapses in the absence of noise.es_ES
dc.description.sponsorshipThis work was supported by the MEyC-FEDER project FIS2009-08451 and the Junta de Andalucia project P07–FQM–02725.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Science (PLOS)es_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es_ES
dc.subjectDepressiones_ES
dc.subjectNeural networkses_ES
dc.subjectNeurons es_ES
dc.subjectNeurotransmissiones_ES
dc.subjectProbability distributiones_ES
dc.subjectSleep es_ES
dc.subjectSynapseses_ES
dc.subjectWhite noisees_ES
dc.titleIrregular Dynamics in Up and Down Cortical Stateses_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES


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