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First synthesis of antitumoral dasyscyphin B

dc.contributor.authorAkhaouzan, Ali
dc.contributor.authorFernández, Antonio
dc.contributor.authorMansour, Ahmed I.
dc.contributor.authorÁlvarez, Esteban
dc.contributor.authorHaidour, Ali
dc.contributor.authorÁlvarez-Manzaneda, Ramón
dc.contributor.authorChahboun Karimi, Rachid 
dc.contributor.authorÁlvarez-Manzaneda, Enrique
dc.date.accessioned2013-09-05T10:09:23Z
dc.date.available2013-09-05T10:09:23Z
dc.date.issued2013-07-23
dc.identifier.citationAkhaouzan, A.; et al. First synthesis of antitumoral dasyscyphin B. Organic and Biomolecular Chemistry, 11(36): 6176-6185 (2013). [http://hdl.handle.net/10481/27971]es_ES
dc.identifier.issn1477-0520
dc.identifier.issn1477-0539
dc.identifier.otherdoi: 10.1039/c3ob41290c
dc.identifier.otherPMID: 23928887
dc.identifier.urihttp://hdl.handle.net/10481/27971
dc.description.abstractThe first synthesis of dasyscyphin B, an antitumoral metabolite obtained from the ascomycete Dasyscyphus niveus, has been achieved starting from commercial abietic acid. The key steps of the synthetic sequence are the diastereoselective α-methylation of a ketoaldehyde, followed by an intramolecular aldol condensation and the further Diels–Alder cycloaddition of a dienol ester. The procedure reported will allow the synthesis of related metabolites functionalized in the A ring.es_ES
dc.description.sponsorshipThe authors thank the Spanish Ministry of Science and Innovation (project CTQ2009-09932) and the Regional Government of Andalucia (project P11-CTS-7651 and assistance to the FQM-348 group) for financial support. A.F. thanks the Spanish Ministry of Science and Innovation for the predoctoral grant provided.es_ES
dc.language.isoenges_ES
dc.publisherRoyal Society of Chemistryes_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es_ES
dc.subjectAntitumorales_ES
dc.subjectDasyscyphus niveuses_ES
dc.titleFirst synthesis of antitumoral dasyscyphin Bes_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES


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