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Design and in vitro evaluation of chlorpheniramine maleate from different eudragit based matrix patches: Effect of platicizer and chemical enhancers.
dc.contributor.author | Rajan, R. | |
dc.contributor.author | Sheba Rani, N.D. | |
dc.contributor.author | Kajal, G. | |
dc.contributor.author | Sanjoy Kumar, D. | |
dc.contributor.author | Jasmina, K. | |
dc.contributor.author | Arunabha, N. | |
dc.date.accessioned | 2013-07-02T10:01:59Z | |
dc.date.available | 2013-07-02T10:01:59Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Rajan, R.;[et. al]. Design and in vitro evaluation of chlorpheniramine maleate from different eudragit based matrix patches: Effect of platicizer and chemical enhancers. Ars Pharm, 2010, Vol.50 nº 4; 177-194.[http://hdl.handle.net/10481/27390] | es_ES |
dc.identifier.issn | 0004-2927 | |
dc.identifier.uri | http://hdl.handle.net/10481/27390 | |
dc.description.abstract | The release and permeation studies were carried out for developing transdermal therapeutic systems with chlorpheniramine maleate (CPM). The patches were prepared with eudragit RS-100 and RL-100 with/without polyvinyl pyrrolidone (PVP) and dibutyl phthalate (DBP) in different compositions. Thickness, tensile strength, drug content, moisture content and water absorption studies of the patches were measured. In vitro release/permeation of CPM was studied in modified Keshary-Chien diffusion cell. Chemical enhancers like l-menthol, oleic acid and phospholipon80 were added to compare the release pattern of the drug. The percent release of the drug from matrix patch increased with increase of PVP & DBP but the tensile strength decreased with the increase of DBP & PVP. Experimental release/permeation data of different formulations of the matrix systems are reported. Also the drug-polymer interaction was investigated by ATR-FTIR studies. The discussion was correlated the efficient matrix dispersion patch from suitable eudragit polymers for transdermal antihistamine applications in film device industry. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Universidad de Granada, Facultad de Farmacia | es_ES |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | es_ES |
dc.subject | Matrix patch | es_ES |
dc.subject | Chlorpheniramine malaeate | es_ES |
dc.subject | Chemical enhancers | es_ES |
dc.subject | Dibutyl phthalate | es_ES |
dc.subject | Eudragit polymer | es_ES |
dc.subject | Polyvinyl pyrrolidone | es_ES |
dc.title | Design and in vitro evaluation of chlorpheniramine maleate from different eudragit based matrix patches: Effect of platicizer and chemical enhancers. | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |