Role of Reproductive Hormones in Islet  Adaptation to Metabolic Stres

Álvarez Mercado, Ana Isabel; Navarro, Guadalupe; Mauvais-Jarvis, Franck

doi:10.1007/978-94-007-6686-0_44

Reprod hormones and metabolic stress.pdf (301.1Ko)

Identificadores

URI: https://hdl.handle.net/10481/110598

DOI: 10.1007/978-94-007-6686-0_44

ISBN: 9789400766853

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Editorial

Springer Nature

Date

2014

Referencia bibliográfica

Published version: Alvarez-Mercado, A.I., Navarro, G., Mauvais-Jarvis, F. (2015). Role of Reproductive Hormones in Islet Adaptation to Metabolic Stress. In: Islam, M. (eds) Islets of Langerhans. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6686-0_44

Patrocinador

Juvenile Diabetes Research Foundation (1-2006-837) NIH RO1 DK074970; March of Dimes (6-FY7-312)

Résumé

There is an interaction between reproduction and energy stores. Both the production and secretion of insulin by pancreatic islet β-cells must adapt to the metabolic demands of various environmental stresses related to reproduction and energy status. These adaptations must occur in a sex specific manner. It is therefore conceivable that reproductive hormones play a role in β-cell adaptation to environmental stresses. This review explores the roles of estrogen, androgen, progesterone, and lactogens in pancreatic β-cell mass and function under conditions of metabolic stress such as pregnancy, obesity, and diabetes.

Colecciones

DF - Capítulos de Libros