The Effects of Virtual Reality Interventions on Motor Function Rehabilitation in Lower-Limb Amputees: A Systematic Review and Metanalysis

Abstract

Background: Lower-limb amputation is a complex condition that profoundly affects motor function and patients’ quality of life. Physical therapists are key in managing lower-limb amputees, and emerging technologies such as virtual reality offer promising tools to further enhance motor function. This review aims to assess the effectiveness of virtual realitybased rehabilitation in improving motor function in lower-limb amputees. Method: A systematic review was conducted using the PubMed, Scopus, and Web of Science databases, covering all studies published from their inception to July 2025. The study population consisted of adult lower-limb amputees receiving virtual reality-based rehabilitation, either alone or combined with other interventions. The search strategy included key terms such as “amputee,” “limb loss,” and “virtual reality,” with no date restrictions. Results: Six studies, all randomized controlled trials, were included and featured a variety of protocols. Meta-analysis showed no significant improvement in walking capacity in the experimental group when compared with controls (p > 0.05). In contrast, postural stability demonstrated significant improvement in the experimental group, with high consistency across studies (I2 = 0%). Conclusions: Current evidence suggests that virtual reality may be an effective approach to improving motor function in lower-limb amputees. However, the studies exhibit methodological limitations, highlighting the need for further research to standardize protocols and evaluate long-term benefits.