Release kinetics of 5-aminosalicylic acid from halloysite

Aguzzi, Carola; Viseras Iborra, César Antonio; Cerezo González, María Pilar; Salcedo, Inmaculada; Sánchez Espejo, Rita María; Valenzuela, Cristóbal

doi:10.1016/j.colsurfb.2012.12.041

Aguzzi et al., 2013-vf.pdf (819.7Kb)

Identificadores

URI: https://hdl.handle.net/10481/101886

DOI: 10.1016/j.colsurfb.2012.12.041

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Materia

Halloysite

5-ASA

Drug release kinetics

Inorganic carrier materials

Fecha

2013

Referencia bibliográfica

Aguzzi, C., Viseras, C., Cerezo, P., Salcedo, I., Sánchez-Espejo, R., Valenzuela, C. (2013). Release kinetics of 5-aminosalicylic acid from halloysite. Colloids and Surfaces B: Biointerfaces, 105, 75-80.

Resumen

This paper investigates desorption of 5-aminosalicilyc acid (5-ASA) adsorbed onto halloysite (HL). Desorptionisotherms were fitted according to kinetic laws obtained considering release of 5-ASA from HL as the phase of desorption of the previously adsorbed drug molecules both inside the nanotubes of HL as onto the surface of clay particles and/or in the inter-particle spaces of their aggregates. Desorption isotherms has been also fitted with other equations frequently used in drug release kinetics studies. The best fitting corresponded to the kinetic model proposed; in agreement with the results of adsorption.

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