Mostrar el registro sencillo del ítem
Differential CD86 and CD40 co-stimulatory molecules and cytokine expression pattern induced by Trypanosoma cruzi in APCs from resistant or susceptible mice
| dc.contributor.author | Morell Hita, María | |
| dc.date.accessioned | 2025-02-03T07:30:56Z | |
| dc.date.available | 2025-02-03T07:30:56Z | |
| dc.date.issued | 2003 | |
| dc.identifier.citation | lanelles L, Thomas MC, Marañón C, Morell M, López MC. Differential CD86 and CD40 co-stimulatory molecules and cytokine expression pattern induced by Trypanosoma cruzi in APCs from resistant or susceptible mice. Clin Exp Immunol. 2003 Jan;131(1):41-7. doi: 10.1046/j.1365-2249.2003.02022.x. PMID: 12519384; PMCID: PMC1808596. | es_ES |
| dc.identifier.uri | https://hdl.handle.net/10481/101808 | |
| dc.description.abstract | Differential aspects of the host immune response generated by Trypanosoma cruzi infection were examined in two different mouse strains, BALB/c (haplotype H2-K d ) which does not overcome the acute phase of the infection and C57BL/6 (haplotype H2-K b ) which survives to the acute phase. After infection an increase in CD3 + T cells was observed in both mouse strains in the peritoneal cavity. However, while the CD3 + T cells from the BALB/c mice showed an increase in the IL-4 cytokine expression level, the same type of cells from the C57BL/6 mice showed an increase in IFNg expression. In addition, only the macrophages from the C57BL/6 mice were activated secreting IL-12 and TNFa and producing, moreover, high levels of nitrites. It was observed that also after parasite infection the expression of macrophage and dendritic cells CD40 and CD86 co-stimulation molecules from the spleen were diminished in BALB/c but not in C57BL/6 mice. In correlation with this observation the macrophages from the spleen of infected BALB/c mice secreted lower concentrations of nitrites than the C57BL/6 mouse cells. Also, the spleen dendritic cells from infected BALB/c mice had a small potential to present alloantigens in contrast to that observed in the infected C57BL/6 mouse cells. | es_ES |
| dc.description.sponsorship | This work was supported by Plan Nacional I +D–FEDER (DGESIC) (grant 1FD1997-0630-C02-01) Spain and Servicio Andaluz de Salud (grant 145/ 2001) Spain | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | Clin Exp Immunol | es_ES |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
| dc.title | Differential CD86 and CD40 co-stimulatory molecules and cytokine expression pattern induced by Trypanosoma cruzi in APCs from resistant or susceptible mice | es_ES |
| dc.type | journal article | es_ES |
| dc.rights.accessRights | open access | es_ES |
| dc.identifier.doi | 10.1046/j.1365-2249.2003.02022.x | |
| dc.type.hasVersion | AM | es_ES |
