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The genetic immunization with paraflagellar rod protein-2 fused to the HSP70 confers protection against late Trypanosoma cruzi infection

dc.contributor.authorMorell Hita, María
dc.contributor.authorThomas, M. Carmen
dc.contributor.authorCaballero Morales, Trinidad 
dc.contributor.authorAlonso, Carlos
dc.contributor.authorLópez, Manuel C.
dc.date.accessioned2025-01-30T10:57:41Z
dc.date.available2025-01-30T10:57:41Z
dc.date.issued2006-07-21
dc.identifier.citationMorell M; Thomas MC; Caballero T; Alonso C; López MC. The genetic immunization with paraflagellar rod protein-2 fused to the HSP70 confers protection against late Trypanosoma cruzi infection. Vaccine 24 (2006) 7046–7055 DOI: 10.1016/j.vaccine.2006.07.006es_ES
dc.identifier.urihttps://hdl.handle.net/10481/101272
dc.descriptionThis work was supported by FIS, Grant nos. PI020565, PI020862, PI051747, C03/04 RICET from MSC and 266/03 from SAS.es_ES
dc.description.abstractThe immunological properties of the Trypanosoma cruzi paraflagellar rod proteins (PFR2 and PFR3) administered alone as well as fused to HSP70 have been analyzed in mice in the context of genetic immunization. The immunization of mice with the DNA vectors containing the PFRs gene or PFRs-HSP70 fused genes induced high level of IgG2a anti-PFRs. However, only the immunization with the PFR2-HSP70 fused genes triggers in spleen cells a statistically significant enhancement of expression of IL-12 and IFN- and a decrease in the percentage of cells expressing IL-4. Likewise, the PFR2-HSP70 molecule elicits a statistically significant activation of PFR2 antigen specific CTLs. Immunization with the PFR2-HSP70 chimeric gene provided a protective response against a T. cruzi experimental infection.es_ES
dc.description.sponsorshipFIS PI020565, PI020862, PI051747es_ES
dc.description.sponsorshipMSC C03/04 RICETes_ES
dc.description.sponsorshipSAS 266/03es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleThe genetic immunization with paraflagellar rod protein-2 fused to the HSP70 confers protection against late Trypanosoma cruzi infectiones_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1016/j.vaccine.2006.07.006
dc.type.hasVersionVoRes_ES


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