Stereoselective Synthesis of Natural Products Promoted by Titanocene(III)

M. Padial, Natalia; Roldan-Molina, Esther; Rosales, Antonio; Álvarez-Corral, Míriam; Rodríguez-García, Ignacio; Muñoz-Dorado, Manuel; Oltra, J. Enrique

doi:10.1016/B978-0-444-64068-0.00002-4

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Identificadores

URI: https://hdl.handle.net/10481/101163

DOI: 10.1016/B978-0-444-64068-0.00002-4

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Editorial

Elsevier

Date

2017-11-14

Sponsorship

To the Spanish “Ministerio de Economı´a y Competitividad” (Project CTQ2015-70724-R cofunded by FEDER), to Campus de Excelencia Internacional Agroalimentario (ceiA3) and to Junta de Andalucı´a (P10-FQM-6050) for financial support. To the Spanish Ministery of Education for the FPU Grant of E.R.-M. (FPU14/01472). N.M.P. acknowledges to Junta de Andalucı´a (P10-FQM-6050) for a scholarship. A.R. acknowledges University of the Sevilla for his position as professor.

Abstract

The use of radical reactions in organic synthesis is increasing every year. Bis(cyclopentadienil)titanium(III) chloride [Cp2TiCl] promotes and catalyzes several transformations under mild conditions compatible with several functional groups. Due to its power as a mild single-electron transfer reagent, Cp2TiCl has become a formidable tool in organic synthesis. Thus, this catalyst is being increasingly used in the synthesis of complex multifunctional molecules, mainly natural products and related compound useful in pharmacology. This chapter will include a comprehensive review of those works on Cp2TiCl-mediated synthesis of natural products published from 2006 onward, as there is a previous comprehensive review covering the subject until 2005.

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