Grupo: Neuroplasticidad y Aprendizaje (CTS1003)
https://hdl.handle.net/10481/62137
2024-03-29T13:18:27ZDifferential activity pattern of c-Fos in the nucleus accumbens between adult and aged rats during flavor recognition memory
https://hdl.handle.net/10481/87662
Differential activity pattern of c-Fos in the nucleus accumbens between adult and aged rats during flavor recognition memory
Grau Perales, Alejandro Borja; Gómez-Chacón, Beatriz; Gallo Torre, Milagros
Previous studies have addressed the role of the nucleus accumbens core (NAcbC) and shell (NAcbSh) in taste aversion learning and in the processing of taste palatability which is affected by aging. However, little is known about its implication in safe taste memory and the aging impact. To explore the role of the NAcb in flavor neophobia and its attenuation during aging, we applied c-Fos immunohistochemistry as an index of neural activity of the NAcbC and NAcbSh. Twenty one adult (5-month-old) and 24 aged (24-month-old) male Wistar rats were exposed to a 3% cider vinegar solution for 1, 2 or 6 consecutive days (n = 7 adult and n = 8 aged rats per group). Aged rats exhibited slower attenuation of flavor neophobia than adult rats. Adult rats showed increased NAcbSh c-Fos activity on day 2 compared to days 1 and 6, while this increase was delayed to day 6 in aged rats. There were no differences in the number of NAcbC c-Fos positive cells. This suggests that changes in the activity of neural circuits of palatability processing during normal aging could contribute to the slower attenuation of flavor neophobia in aged rats.
Encuentros en Neurociencias Vol. VI
https://hdl.handle.net/10481/87590
Encuentros en Neurociencias Vol. VI
Gámiz, Fernando; Rivera Sánchez, Margarita
Encuentros en Neurociencias Vol. VI recoge los trabajos de investigación, llevados a cabo entre 2019 y 2020, de los diferentes grupos de investigación que componen el Instituto de Neurociencias "Federico Olóriz" de la Universidad de Granada.
Esta colección, iniciada en 2010, responde al compromiso del Instituto de Neurociencias con la formación de sus miembros más jóvenes, así como en la difusión del trabajo que desarrollan los distintos grupos de investigación. En este volumen encontraréis desde trabajos de investigación básica con modelos animales hasta estudios de los aspectos más psicosociales y clínicos de diferentes enfermedades, donde el eje vertebrador es nuestro interés en la neurociencia, como campo especialmente fructífero y prometedor.
Nuestro agradecimiento a la dirección del Instituto de Neurociencias y a los coautores que, a pesar de las dificultades sobrevenidas por la actual pandemia de COVID-19, han ofrecido su inestimable ayuda para continuar esta publicación periódica que muestra la evolución y presente de las Neurociencias.
The auditory context-dependent attenuation of taste neophobia depends on D1 dopamine receptor activity in mice.
https://hdl.handle.net/10481/87567
The auditory context-dependent attenuation of taste neophobia depends on D1 dopamine receptor activity in mice.
Grau Perales, Alejandro Borja; Gallo Torre, Milagros
aste recognition memory in rodents is evident as taste neophobia disappears upon repeated taste exposures without aversive consequences, thus increasing the consumption of familiar edibles. The attenuation of taste neophobia (AN) induced by taste familiarity is auditory context-dependent in mice since neophobia to a familiar taste reappears with a novel auditory background. This effect depends on the integrity of the dorsal hippocampus but the potential role of dopamine has remained unexplored. In order to explore the involvement of dopamine through D1 dopamine receptors in AN, C57BL/6 mice were exposed to a 3% vinegar taste solution for 10 min throughout several consecutive days. An experimentally-controlled auditory background was used to define a context, which could either change or remain constant throughout all the drinking sessions. Systemic administration of the D1 dopamine receptor antagonist SCH-23390 induced a similar effect to that of an auditory context change while it was kept constant and systemic administration of SKF-81297 prevented the contextual modulation of AN when the auditory context changed. Additionally, SCH-23390 injection on the following day to the auditory context change further impaired AN, thus suggesting the relevance of dopamine in the consolidation of the context dependency of taste recognition memory. We conclude that the context dependency of the AN involves dopaminergic activity mediated by D1 receptors which might be responsible for proper acquisition of safe taste recognition memory.
Prefrontal cortex activity patterns during taste neophobia habituation in adult and aged rats
https://hdl.handle.net/10481/87562
Prefrontal cortex activity patterns during taste neophobia habituation in adult and aged rats
Navarro Expósito, Alejandro; Morillas, Enrique; Gómez-Chacón, Beatriz; Gallo, Milagros
Age-related memory decline has been associated with changes in the medial prefrontal cortex (mPFC) function. In order to explore the role of mPFC in taste recognition memory, we have assessed mPFC c-Fos immunoreactivity in adult (5-month-old) and aged (24-month-old) male Wistar rats during the first (Novel), second (Familiar I), and sixth (Familiar II) exposure to a cider vinegar solution. Adult brains showed higher c-Fos expression in the ventral but not the dorsal region of mPFC during the second taste exposure. Interestingly, old brains exhibited an altered activity pattern selectively in the dorsal peduncular cortex (DP) which can be associated with a delayed attenuation of vinegar neophobia in this group. These results support the involvement of this area in the formation of safe taste memory. Further research is needed for understanding the role of DP in taste recognition memory and the impact of aging on it.
Flavor recognition memory related activity of the posterior piriform cortex in adult and aged rats
https://hdl.handle.net/10481/87389
Flavor recognition memory related activity of the posterior piriform cortex in adult and aged rats
Grau Perales, Alejandro Borja; Gómez Chacón, Beatriz; Morillas, Enrique; Gallo Torre, Milagros
The relationship between the piriform cortex and flavor recognition memory was investigated in adult and aged rats. By using c-Fos immunohistochemistry, we assessed the piriform cortex activity induced by flavor familiarity. The results indicated increased activity in the rostral region of the posterior piriform cortex elicited by the most familiar cider vinegar solution after six exposures. Aged rats exhibited overall increased activity in the posterior, but not the anterior piriform cortex, which was not related to flavor familiarity. This suggests that the posterior piriform cortex is related to flavor recognition memory and that aging modifies its activity pattern
which might underlie their slower attenuation of flavor neophobia.