https://hdl.handle.net/10481/48060 2026-04-26T18:33:53Z 2026-04-26T18:33:53Z Sorlozano Puerto, Antonio Gómez Luque, José María Luna Del Castillo, Juan De Dios Navarro Mari, José María Gutiérrez Fernández, José https://hdl.handle.net/10481/58148 2021-06-15T13:08:23Z

Etiological and Resistance Profile of Bacteria Involved in Urinary Tract Infections in Young Children Sorlozano Puerto, Antonio; Gómez Luque, José María; Luna Del Castillo, Juan De Dios; Navarro Mari, José María; Gutiérrez Fernández, José The objective of this study was to identify the bacteria most frequently responsible for urinary tract infection (UTI) in the population of under-2-year-olds in our geographic area and to evaluate the activity of antibiotics widely used for UTI treatment during a 4-year study period. Materials and Methods. A retrospective analysis was conducted of data on the identification and susceptibility of microorganisms isolated in urine samples from children under 2 years of age. A total of 1,045 uropathogens were isolated. Escherichia coli accounted for the majority (60.3%) of these, followed by Enterococcus faecalis (22.4%) and Klebsiella spp. (6.5%). The highest E. coli susceptibility rates (>90%) were to piperacillin-tazobactam, cefuroxime, cefotaxime, ceftazidime, imipenem, gentamicin, nitrofurantoin, and fosfomycin, and the lowest were to amoxicillin-clavulanic acid and cotrimoxazole. Among all bacteria isolated, we highlight the overall high activity of piperacillin-tazobactam, imipenem, nitrofurantoin, and fosfomycin against both community and hospital isolates and the reduced activity of amoxicillin-clavulanic acid, cephalosporins, gentamicin, and cotrimoxazole. There was no significant change in the total activity of any of the studied antibiotics over the 4-year study period. Empiric treatment with amoxicillin-clavulanic acid, cotrimoxazole, cephalosporins, and gentamicin may be inadequate due to their limited activity against uropathogens in our setting