Departamento de Pediatríahttps://hdl.handle.net/10481/311492024-03-29T07:29:57Z2024-03-29T07:29:57ZBone mineralization status measured by dual energy radiographic densitometry in preterm infants fed commercial formulasNarbona López, EduardoMaldonado Lozano, JoséOcete Hita, EstherGil Hernández, ÁngelMolina Font, Juan Antoniohttps://hdl.handle.net/10481/881932024-02-04T19:24:26ZBone mineralization status measured by dual energy radiographic densitometry in preterm infants fed commercial formulas
Narbona López, Eduardo; Maldonado Lozano, José; Ocete Hita, Esther; Gil Hernández, Ángel; Molina Font, Juan Antonio
We have studied the effect of two preterm commercial infant formulas with different calcium
and phosphorus contents on the mineral balance and bone mineralization of 30 preterm infants
at 1 month of age. Bone mineralization was measured by dual energy X-ray densitometry. The
formula supplying a higher content of calcium and phosphorus promoted higher mineral
retention (P , 0.01) as well as higher bone mineral content (1.556 vs. 1.073 g, P , 0.01) and
2
bone mineral density (0.458 vs. 0.424 g / cm , P , 0.05), approaching values of the control
group, which comprised a cohort of 15 preterm newborns whose gestational age was 4 weeks
older than the subjects selected to be fed with the formulas. The intake of calcium correlated
with retention (r 5 0.69); the phosphorus intake also correlated with phosphorus retention
(r 5 0.95). Intakes of calcium and phosphorus correlated with the bone mineral content
(r 5 0.65) and with bone mineral density (r 5 0.49). We conclude that formulas for preterm
infants should not have a calcium content lower than 120 mg / 100 kcal and should have a
calcium / phosphorus ratio of about 2 to promote adequate bone mineralization.
Low-dosage prophylactic vancomycin in centralvenous catheters for neonatesOcete Hita, EstherRuız-Extremera, ÁngelaGoicoechea, AlejandroLozano, ElisaRobles Vizcaino, ConcepciónRey, María LuisaSalmerón Escobar, Francisco Javierhttps://hdl.handle.net/10481/881882024-02-04T18:17:00ZLow-dosage prophylactic vancomycin in centralvenous catheters for neonates
Ocete Hita, Esther; Ruız-Extremera, Ángela; Goicoechea, Alejandro; Lozano, Elisa; Robles Vizcaino, Concepción; Rey, María Luisa; Salmerón Escobar, Francisco Javier
Neonatal infectious pathology remains one of the main causes of morbidity and mortality in
this age group. The introduction of plasticized catheters for the administration of medication,
fluidotherapy and parenteral nutrition was a significant advance in treatment of patients at risk,
but also led to the appearance of infectious complications. Negative coagulase staphylococcus
is the principal pathogen in most neonatal intensive care units. Recent studies have examined
the prophylactic use of vancomycin in preterm babies receiving parenteral nutrition. We have
evaluated the efficacy of this procedure, applied via the central venous catheters employed for
all neonates, within the intensive care unit over a period of one year. Prophylactic vancomycin
administered via the catheters significantly reduced the incidence of Gram-positive infections,
despite the presence within this group of a greater number of septic risk factors than in the
control group.
Incidencia de infecciones por Cándida en el recién nacido de muy bajo peso. Importancia de un diagnóstico precoz y valoración de las actitudes terapéuticasOcete Hita, EstherLoscertales Abril, MercedesRuiz Extremera, ÁngelesCarreño Losilla, J.Mantas, J. A.Narbona López, Eduardohttps://hdl.handle.net/10481/881522024-02-04T16:54:53ZIncidencia de infecciones por Cándida en el recién nacido de muy bajo peso. Importancia de un diagnóstico precoz y valoración de las actitudes terapéuticas
Ocete Hita, Esther; Loscertales Abril, Mercedes; Ruiz Extremera, Ángeles; Carreño Losilla, J.; Mantas, J. A.; Narbona López, Eduardo
Post-transfusional hepatitis in neonates hospitalized in a Neonatal Intensive Care UnitRuiz Extremera, ÁngelesSalmerón Escobar, Francisco JavierRey, M. L.Torres, C.Muñoz de Rueda, PalomaOcete Hita, EstherLuna Del Castillo, Juan De Dioshttps://hdl.handle.net/10481/880962024-02-04T15:20:23ZPost-transfusional hepatitis in neonates hospitalized in a Neonatal Intensive Care Unit
Ruiz Extremera, Ángeles; Salmerón Escobar, Francisco Javier; Rey, M. L.; Torres, C.; Muñoz de Rueda, Paloma; Ocete Hita, Esther; Luna Del Castillo, Juan De Dios
Neurodevelopment of neonates in neonatal intensive care units and growth of surviving infants at age 2 yearsRuiz-Extremera, AngelaRobles Vizcaino, ConcepciónSalvatierra-Cuenca, María TeresaOcete Hita, EstherLainez, CarolinaBenítez Feliponi, ÁngelaCruz, FranciscoMiranda, María-TeresaSalmerón, Javierhttps://hdl.handle.net/10481/880782024-02-04T09:02:22ZNeurodevelopment of neonates in neonatal intensive care units and growth of surviving infants at age 2 years
Ruiz-Extremera, Angela; Robles Vizcaino, Concepción; Salvatierra-Cuenca, María Teresa; Ocete Hita, Esther; Lainez, Carolina; Benítez Feliponi, Ángela; Cruz, Francisco; Miranda, María-Teresa; Salmerón, Javier
Summary: The presence of development disorders in neonates attended in a Neonatal Intensive Care Unit (NICU) is highly variable; the aim of this study, therefore, was to determine the evolution of somatic and neurosensory development in a group of neonates requiring treatment in the NICU and to analyse the perinatal and developmental aspects of children presenting abnormalities. Patients and methods: A total of 492 neonates (275 premature, 106 with birthweight ≤1500 g), who were treated in the NICU between January 1994 and December 1997, were followed-up until the age of 2 years. Data were obtained concerning birthweight, body length, head circumference, gestational age, normality of weight for gestational age, single/multiple birth, duration of stay in the NICU and the hospital, duration of mechanically assisted respiration and evolutive somatometry, neurological examination and the Brunet–Lezine development test, adjusted for the gestational age of the neonates, at 6, 12, 18 and 24 months. When abnormal results were detected, Early Attention (EA) programmes were applied. Results: Somatometry at birth in relation to gestational age revealed a weekly weight gain of 8.6%, an increase in body length of 1% and in head circumference of 1% (p<0.001). The evolution of somatic development to the age of 2 years showed that neonates with a birthweight ≤1500 g did not reach the values of neonates with a greater birthweight. The prevalence of cerebral palsy among all neonates was 6.8%, 14.6% among those weighing ≤1500 g, 4% among those weighing 1501–2500 g and 5% among those weighing >2500 g. The overall rate of neurosensory injury was 10.5%. These neonates presented less somatic development than those did with no neurologic disorder. To sum up, most of the neonates attended in the NICU during the 1990s presented a normal pattern of development. Nevertheless, they should be the object of special attention during the first years of life, particularly those neonates with a birthweight ≤1500 g and those presenting neurosensory risk.