Departamento de Química Farmacéutica y Orgánicahttps://hdl.handle.net/10481/311322024-03-28T11:59:28Z2024-03-28T11:59:28ZSynthesis of 1,4-benzoxathiin-9H-purine derivatives as antiproliferative agentsCruz López, Olga MaríaCampos Rosa, Joaquín MaríaConejo García, Anahttps://hdl.handle.net/10481/879592024-02-02T07:31:02ZSynthesis of 1,4-benzoxathiin-9H-purine derivatives as antiproliferative agents
Cruz López, Olga María; Campos Rosa, Joaquín María; Conejo García, Ana
Benzo‐Fused Seven‐ and Six‐Membered Derivatives Linked to Pyrimidines or Purines Induce Apoptosis of Human Metastatic Breast Cancer MCF‐7 Cells in VitroCampos Rosa, Joaquín MaríaConejo García, AnaCruz López, Olga MaríaNúñez Carretero, María Del Carmenhttps://hdl.handle.net/10481/879582024-02-01T13:43:17ZBenzo‐Fused Seven‐ and Six‐Membered Derivatives Linked to Pyrimidines or Purines Induce Apoptosis of Human Metastatic Breast Cancer MCF‐7 Cells in Vitro
Campos Rosa, Joaquín María; Conejo García, Ana; Cruz López, Olga María; Núñez Carretero, María Del Carmen
Synthesis and Biological Evaluation of Novel Allosteric Enhancers of the A1 Adenosine Receptor Based on 2-Amino-3-(4’-Chlorobenzoyl)-4-Substituted-5-Arylethynyl ThiopheneRomagnoli, RomeoCruz López, Olga MaríaLópez Cara, Luisa Carlotahttps://hdl.handle.net/10481/879542024-02-01T13:24:46ZSynthesis and Biological Evaluation of Novel Allosteric Enhancers of the A1 Adenosine Receptor Based on 2-Amino-3-(4’-Chlorobenzoyl)-4-Substituted-5-Arylethynyl Thiophene
Romagnoli, Romeo; Cruz López, Olga María; López Cara, Luisa Carlota
Bozepinib: A Promising Selective Derivative Targeting Breast Cancer Stem CellsCampos Rosa, Joaquín MaríaConejo García, AnaCruz López, Olga Maríahttps://hdl.handle.net/10481/879532024-02-01T13:24:23ZBozepinib: A Promising Selective Derivative Targeting Breast Cancer Stem Cells
Campos Rosa, Joaquín María; Conejo García, Ana; Cruz López, Olga María
Relationship between HMF intake and SMF formation in vivo: An animal and human studyPastoriza de la Cueva, SilviaMontilla Gómez, JavierCruz López, Olga MaríaDelgado-Andrade, CristinaRufián Henares, José Ángelhttps://hdl.handle.net/10481/879512024-02-01T13:19:26ZRelationship between HMF intake and SMF formation in vivo: An animal and human study
Pastoriza de la Cueva, Silvia; Montilla Gómez, Javier; Cruz López, Olga María; Delgado-Andrade, Cristina; Rufián Henares, José Ángel
Scope
5-Hydroxymethylfurfural (HMF) is a furanic compound produced in heat-processed foods by nonenzymatic browning reactions. HMF has been demonstrated to be hepato- and nephrotoxic in animals with a link to its metabolite 5-sulfooxymethylfurfural (SMF). To date little is known about either the formation of SMF from ingested HMF or the formation of DNA adducts in animals or human beings.
Methods and results
To assess SMF in vivo formation, we first performed a study in mice treated with high/low doses of oral HMF. We found increased concentrations of SMF in plasma and DNA SMF-adducts in leukocytes, hepatic tissue, and kidneys by means of LC–MS/MS, but no spatial formation in such tissues was observed by MALDI-MS imaging technology due to low sensitivity. In a second experiment, we measured the exposure to HMF in a Spanish preadolescent population. We analyzed the concentration of HMF metabolites (plasma, urine) and measured, for the first time, the presence of SMF in plasma and DNA SMF-adducts in leukocytes.
Conclusion
This study provides the first evidence that oral HMF is readily transformed into SMF in vivo, giving rise to the formation of DNA adducts in a direct relation with HMF intake, both in animals and human beings.