Departamento de Farmacia y Tecnología Farmacéuticahttps://hdl.handle.net/10481/310572024-03-28T14:13:37Z2024-03-28T14:13:37ZA Narrative Review: Analysis of Supplemental Parenteral Nutrition in Adults at the End of LifeRivas García, FranciscoGiménez Martínez, Rafael JesúsHuertas Camarasa, Felipe JoséMarch Cerdá, Joan CarlesLloris Messeguer, FuensantaLópez-Viota Gallardo, Margaritahttps://hdl.handle.net/10481/888442024-02-09T10:49:25ZA Narrative Review: Analysis of Supplemental Parenteral Nutrition in Adults at the End of Life
Rivas García, Francisco; Giménez Martínez, Rafael Jesús; Huertas Camarasa, Felipe José; March Cerdá, Joan Carles; Lloris Messeguer, Fuensanta; López-Viota Gallardo, Margarita
“End of life” is a stage defined by the existence of an irreversible prognosis that ends with a
person’s death. One of the aspects of interest regarding end of life focuses on parenteral nutrition,
which is usually administered in order to avoid malnutrition and associated complications. However,
parenteral nutrition can be adapted to specific circumstances and evolve in its functionality through
supplementation with certain nutrients that can have a beneficial effect. This narrative review aims to
carry out a situation analysis of the role that could be adopted by supplemental parenteral nutrition
in attenuating alterations typical of end of life and potential improvement in quality of life.
Environmentally Friendly Strategies for Formulating Vegetable Oil-Based Nanoparticles for Anticancer MedicineFreire, NatháliaGarcía Villén, FátimaViseras Iborra, César Antoniohttps://hdl.handle.net/10481/852682023-11-28T23:14:16ZEnvironmentally Friendly Strategies for Formulating Vegetable Oil-Based Nanoparticles for Anticancer Medicine
Freire, Nathália; García Villén, Fátima; Viseras Iborra, César Antonio
The development of green synthesized polymeric nanoparticles with anticancer studies has
been an emerging field in academia and the pharmaceutical and chemical industries. Vegetable oils are
potential substitutes for petroleum derivatives, as they present a clean and environmentally friendly
alternative and are available in abundance at relatively low prices. Biomass-derived chemicals can
be converted into monomers with a unique structure, generating materials with new properties
for the synthesis of sustainable monomers and polymers. The production of bio-based polymeric
nanoparticles is a promising application of green chemistry for biomedical uses. There is an increasing
demand for biocompatible and biodegradable materials for specific applications in the biomedical
area, such as cancer therapy. This is encouraging scientists to work on research toward designing
polymers with enhanced properties and clean processes, containing oncology active pharmaceutical
ingredients (APIs). The nanoencapsulation of these APIs in bio-based polymeric nanoparticles can
control the release of the substances, increase bioavailability, reduce problems of volatility and
degradation, reduce side effects, and increase treatment efficiency. This review discusses the use of
green chemistry for bio-based nanoparticle production and its application in anticancer medicine.
The use of castor oil for the production of renewable monomers and polymers is proposed as an ideal
candidate for such applications, as well as more suitable methods for the production of bio-based
nanoparticles and some oncology APIs available for anticancer application
Multi-stimuli-responsive chitosan-functionalized magnetite/poly(ε-caprolactone) nanoparticles as theranostic platforms for combined tumor magnetic resonance imaging and chemotherapyGarcía García, GraciaFernández Álvarez, FátimaArias Mediano, José Luishttps://hdl.handle.net/10481/852102023-10-24T10:17:23ZMulti-stimuli-responsive chitosan-functionalized magnetite/poly(ε-caprolactone) nanoparticles as theranostic platforms for combined tumor magnetic resonance imaging and chemotherapy
García García, Gracia; Fernández Álvarez, Fátima; Arias Mediano, José Luis
Chitosan-functionalized magnetite/poly(ε-caprolactone) nanoparticles were formulated by interfacial polymer disposition plus coacervation,
and loaded with gemcitabine. That (core/shell)/shell nanostructure was confirmed by electron microscopy, elemental analysis, electrophoretic,
and Fourier transform infrared characterizations. A short-term stability study proved the protection against particle aggregation
provided by the chitosan shell. Superparamagnetic properties of the nanoparticles were characterized in vitro, while the definition of the
longitudinal and transverse relaxivities was an initial indication of their capacity as T2 contrast agents. Safety of the particles was demonstrated
in vitro on HFF-1 human fibroblasts, and ex vivo on SCID mice. The nanoparticles demonstrated in vitro pH- and heat-responsive gemcitabine
release capabilities. In vivo magnetic resonance imaging studies and Prussian blue visualization of iron deposits in tissue samples defined the
improvement in nanoparticle targeting into the tumor when using a magnetic field. This tri-stimuli (magnetite/poly(ε-caprolactone))/chitosan
nanostructure could find theranostic applications (biomedical imaging & chemotherapy) against tumors.
Investigation into Brazilian Palygorskite for Its Potential Use as Pharmaceutical Excipient: Perspectives and ApplicationsAraújo Meirelles, Lyghia MariaDe Melo Barbosa, RaquelSánchez Espejo, Rita MaríaGarcía Villén, FátimaViseras Iborra, César Antoniohttps://hdl.handle.net/10481/846382023-09-25T10:28:55ZInvestigation into Brazilian Palygorskite for Its Potential Use as Pharmaceutical Excipient: Perspectives and Applications
Araújo Meirelles, Lyghia Maria; De Melo Barbosa, Raquel; Sánchez Espejo, Rita María; García Villén, Fátima; Viseras Iborra, César Antonio
Palygorskite is an aluminum and magnesium silicate characterized by its fibrous morphology, providing it with great versatility in industrial applications, including pharmaceuticals. Although most of the reserves are in the United States, in recent years occurrences of commercially exploited deposits in Brazil have been recorded, mainly in the country’s northeast region. This has motivated this study, which analyzes raw Brazilian palygorskite compared to a commercial sample (Pharmasorb® colloidal) to demonstrate its pharmaceutical potential. The chemical and mineral composition of the samples were evaluated for surface properties, granulometry, morphology, crystallography, thermal analysis, and spectroscopy. Raw palygorskite presented 67% purity, against 74% for Pharmasorb® colloidal. The percentage purity relates to the presence of contaminants, mainly carbonates and quartz (harmless under conventional conditions of pharmaceutical use). Furthermore, it was possible to confirm the chemical composition of these phyllosilicates, formed primarily of silicon, aluminum, and magnesium oxides. The crystallographic and spectroscopic profiles were consistent in both samples, showing characteristic peaks for palygorskite (2θ = 8.3°) and bands attributed to fibrous phyllosilicates below 1200 cm−1, respectively. The thermal analysis allowed the identification of the main events of palygorskite, with slight differences between the evaluated samples: loss of water adsorbed onto the surface (~85 °C), removal of water contained in the channels (~200 °C), coordinated water loss (~475 °C), and, finally, the dehydroxylation (>620 °C). The physicochemical characteristics of raw palygorskite align with pharmacopeial specifications, exhibiting a high specific surface area (122 m2/g), moderately negative charge (−13.1 mV), and compliance with the required limits for heavy metals and arsenic. These favorable technical attributes indicate promising prospects for its use as a pharmaceutical ingredient in the production of medicines and cosmetics.
Medication Review with Follow-Up for End-Stage Renal Disease: Drug-Related Problems and Negative Outcomes Associated with Medication—A Systematic ReviewPereira-Céspedes, AlfonsoJiménez Morales, AlbertoPalomares-Bayo, MagdalenaMartínez Martínez, FernandoCalleja Hernández, Miguel Ángelhttps://hdl.handle.net/10481/845742023-10-09T22:22:10ZMedication Review with Follow-Up for End-Stage Renal Disease: Drug-Related Problems and Negative Outcomes Associated with Medication—A Systematic Review
Pereira-Céspedes, Alfonso; Jiménez Morales, Alberto; Palomares-Bayo, Magdalena; Martínez Martínez, Fernando; Calleja Hernández, Miguel Ángel
Background: This article reviews the available scientific literature on drug-related problems and negative outcomes associated with medications identified by medication review with follow-up for end-stage renal disease and discussed with the physicians. Methods: A systematic review was conducted of the scientific literature retrieved from the following databases: MEDLINE (via PubMed), Web of Science, SCOPUS, Cochrane Library: The Cochrane Central Register and Control Trials (CENTRAL) and Literatura Latinoamericana y del Caribe (LILACS), Medicina en Español (MEDES), and the SciELO bibliographic database (a collection of scientific journals). The following terms were used as descriptors and searched in free text: “end-stage renal disease”, “medication review”, “drug-related problems”, and “negative outcomes associated with medication”. The following limits were applied: “humans” and “adults (more than 18 years)”. Results: A total of 59 references were recovered and, after applying inclusion/exclusion criteria, 16 articles were selected. Of these selected articles, 15 provided information on drug-related problems and only 1 on negative outcomes associated with medications. Conclusions: It can be concluded that drug-related problems and negative outcomes associated with medications affect patients with end-stage renal disease, mainly those receiving renal replacement therapy. More evidence is needed, especially on negative outcomes associated with medication.
Financial support received as a Doctoral Grant [reference number OAICE-143-2020] from the Office of International Affairs and External Cooperation, University of Costa Rica.