Producción Científica de la Universidad de Granada https://hdl.handle.net/10481/190 2026-04-06T12:09:49Z 2026-04-06T12:09:49Z Sánchez-Román, Mónica Naim, Zeina Sánchez Navas, Antonio Waajen, Annemiek C. Yao, Tingting Sankar Gupta, Karthick Sai Nieto García, Fernando https://hdl.handle.net/10481/112622 2026-04-06T11:01:16Z

Microbial and clay-mediated dolomite formation in a saline playa-lake: Implications for biosignatures on Mars Sánchez-Román, Mónica; Naim, Zeina; Sánchez Navas, Antonio; Waajen, Annemiek C.; Yao, Tingting; Sankar Gupta, Karthick Sai; Nieto García, Fernando This study investigates the authigenesis of palygorskite in association with dolomite, as well as the alteration of detrital clays into vermiculite and Mg/Fe smectites, within the upper sediments of the semi-arid saline playa lake system of Laguna Fuente de Piedra (southern Spain). A combination of analytical techniques, including XRD, SEM-EDS, HRTEM-AEM, ICP-MS/OES, NMR, and 16S rRNA gene sequencing, was used to characterize sediment mineralogy, microtextures, geochemistry, and microbial assemblages. The results reveal an assemblage of authigenic dolomite and clays embedded within an extracellular polymeric substance (EPS) matrix, consistent with microbially influenced mineralization at low temperature. These findings provide new insight into how clay minerals modulate microenvironments (e.g., ion activity, fluid and pore-water composition) and offer reactive surfaces that facilitate dolomite precipitation, while also acting as substrates for microbial colonization and EPS preservation in inland saline lake settings (e.g., playa lakes, continental sabkhas). Because evaporitic to alkaline lacustrine environments and Mg-rich carbonates and clay minerals have been documented or inferred for ancient Martian basins, the co-occurrence of Mg-carbonates with Fe/Mg-rich clays constitutes a testable mineralogical target for biosignature investigations on Mars. In particular, when evaluated together with diagnostic microtextures and complementary geochemical indicators, this assemblage may help distinguish purely abiotic precipitation from microbially influenced mineralization in Martian sedimentary records. This work was supported by the Dutch Research Council (NWO) under project numbers OCENW.KLEIN.037 and ENW.GO.001.033 awarded to MSR. MSR also acknowledges financial support from the Beatriz Galindo Senior Grant (No. BG23-00132), funded by the Spanish Ministry of Science, Innovation and Universities (MICIU). E.M. Marín Martín is kindly acknowledged for her kind assistance and help in the lab.

Díaz Díaz, Pedro Rafael https://hdl.handle.net/10481/112620 2026-04-06T10:45:37Z

Definiciones varias de Iglesia Díaz Díaz, Pedro Rafael Constituye este trabajo la primera versión directa e íntegra al español del opúsculo leibniziano titulado “Definiciones varias de Iglesia” (= Variae definitiones Ecclesiae), realizada sobre la edición crítica del texto de AA VI, 4C, 2174-2179. No se trata, sin embargo, de una mera traslación descontextualizada al español; por el contrario, las numerosas y detalladas Notas filológicas, que acompañan a la versión española, persiguen como objetivo prioritario identificar los autores, las obras y, en su caso, el pasaje concreto que están en la base de la especulación leibniziana sobre el tema de la reunificación de las Iglesias.; This work represents the first direct and whole translation into Spanish of leibnitian brief treatise entitled “Different definitions of Church” (= Variae definitiones Ecclesiae). It is hurried out on text critical edition AA VI, 4C, 2174-2179. It doesn’t only consist of a simple translation out of context; on the contrary, the wide range of philological quotations in the Spanish version train to reach the main goal of identifying the authors, the plays and, in its case, the specific passage which are on the basis of leibnitian speculation on the matter of the reunification of the Churches.

Moral Soriano, Leonor https://hdl.handle.net/10481/112618 2026-04-06T10:30:00Z

Right not to use the Internet: Lessons to be learned from the right not to be subject to automated decisions Moral Soriano, Leonor It is widely acknowledged that new rights emerge when the existing legal framework fails to adequately protect the political and moral values of a society. Several factors can contribute to this inadequacy (Serna 2024: 19). Among these is the belief that current rights are insufficient to address new challenges (such as the digital ones); additionally, technological and scientific advancements, such as the use of “black boxes” in decision- making processes, further require the establishment of new rights. However, sometimes the best answer to deal with these defies are not new rights but a reinforced interpretation of existing rights (Serna 2024: 21).1 In this sense, the right not to use Internet can be conceptualized as an specific interpretation of the fundamental right of privacy (data protection); likewise, the right to be free from automated decisions may be considered a concretization of the right to judicial protection (and, ultimately, the Rule of Law). In particular, automated decision- making (ADM) systems are artificial intelligence technologies designed to assist or even replace human judgments. Applied in the legal domain, this technology is used by legal operators. The idea of a robot judge or machine judge is unsettling, though it has ceased to be a science fiction image, and national legislations, such as in Spain, already regulate AI- assisted judicial decisions.2 On the other hand, the use of ADM systems by the public authorities and governmental bodies is a well- established and widespread practice in all public services areas: health, education, contracting, transportation, etc. What is challenging is the use of ADM systems by public bodies to take decisions that have legal effects on citizens, so that it will be an algorithm that, via assistance or substitution, determines the sphere of rights and interests of those affected by the activity of governmental bodies. ADM systems present formidable challenges for the legal framework: transparency, accessibility, accountability, fairness, biases, and the delegation of legal powers to machines, among others. To confront these challenges and safeguard the rationality of legal systems, some scholars advocate for establishing a human right to not be subject to automated decisions. I will explore the necessity of this new right from both a functional perspective (do we require a new right?) and a normative standpoint (why is the creation of a new right imperative?). These functional right not to use the Internet, which is the main theme of this book. In addressing these inquiries, I will focus on the utilization of ADM by legal practitioners, particularly by public bodies whose decisions, whether partially or fully automated, directly impact individual rights. Do we truly need a new right not to be subjected to automated legal decisions? Are the “classic” rights providing us with sufficient protection?

Pérez Cámara, Noelia Teva Álvarez, Inmaculada María Pérez García, Miguel Lozano Fernández, Luis Manuel Hidalgo Ruzzante, Natalia Adriana https://hdl.handle.net/10481/112617 2026-04-06T10:26:08Z

Exposure to different types of violence during childhood and adolescence: Risk factors for perpetrating intimate partner violence against women in early adulthood Pérez Cámara, Noelia; Teva Álvarez, Inmaculada María; Pérez García, Miguel; Lozano Fernández, Luis Manuel; Hidalgo Ruzzante, Natalia Adriana Purpose. Due to the prevalence and severity of Intimate Partner Violence against Women (IPVAW), there is a growing literature focused on understanding the risk factors for perpetrating it. The aim of the present study is to analyse whether exposure to IPVAW in the family of origin, experiencing childhood maltreatment, perpetrating and/or experiencing bullying, as well as being involved in antisocial behaviours during childhood and adolescence, increase the risk of male IPVAW perpetration in adulthood. Methodology. Data were extracted from the Avon Longitudinal Study of Parents and Children (ALSPAC). The sample consisted of 1,011 men from the general population, categorized into two groups: those who engaged in any form of IPVAW (psychological, physical, and/or sexual violence) (n = 163) and those who reported no violent behavior (n = 848) at 21.5 years old. Findings. Prevalence of IPVAW perpetration was estimated, and the percentages of the variables of interest among male IPVAW perpetrators were reported. The results showed that exposure to IPVAW in the family of origin, experiencing childhood maltreatment, perpetrating bullying, as well as being involved in antisocial behaviours during childhood and adolescence, increased the risk of IPVAW perpetration in adulthood. Originality. The findings could be useful in prevention programs. Additionally, they highlight the importance of including childhood and adolescent experiences of violence in intervention programs for male IPVAW perpetrators.

Gale, Daniel Agraz Pamplona, Irene Zainab, Arslan Esteban de la Rosa, Rafael José Hall, Matthew Krejci, Karel Morales, Enrique Safranek, Roman Tesar, Vladimir Torra, Roser Lennon, Rachel https://hdl.handle.net/10481/112615 2026-04-06T10:18:42Z

Safety and preliminary efficacy findings from a phase 2a randomized, double-blind, placebo-controlled trial of setanaxib in patients with Alport syndrome Gale, Daniel; Agraz Pamplona, Irene; Zainab, Arslan; Esteban de la Rosa, Rafael José; Hall, Matthew; Krejci, Karel; Morales, Enrique; Safranek, Roman; Tesar, Vladimir; Torra, Roser; Lennon, Rachel The study (NCT06274489), evaluated setanaxib—a first-in-class NOX1/4 inhibitor—as a treatment to reduce fibrosis and inflammation in Alport syndrome (AS). Key Findings from the Trial 1. Safety (Primary Endpoint) The study met its primary safety objective. Setanaxib was generally well-tolerated over the 24-week period. • Adverse Events (AEs): Occurred at similar frequencies in both the setanaxib and placebo groups. • Serious Adverse Events (SAEs): One SAE (acute cholecystitis) was reported in the setanaxib group, but it was determined to be unrelated to the treatment. • Discontinuations: No patients discontinued the study due to drug-related side effects. 2. Efficacy (Secondary Endpoints) While the study was a small Phase 2a trial (N=20), it showed a positive trend in reducing proteinuria, a key marker of kidney disease progression. • UPCR Reduction: The setanaxib group showed a 15% mean reduction in the Urine Protein-Creatinine Ratio (UPCR) at 24 weeks compared to placebo. • Post-Dosing Effect: Interestingly, the reduction improved to 27% at four weeks after the treatment period ended. • Response Rate: 15.4% of patients on setanaxib achieved a \ge 25\% reduction in UPCR, whereas no patients in the placebo group reached this threshold. 3. Kidney Function (eGFR) • There was a slight mean reduction in eGFR (5% at 24 weeks) in the setanaxib group compared to placebo, which is often observed with therapies that alter glomerular hemodynamics. Study Design Overview • Participants: 20 patients (aged 12–50) with genetically confirmed Alport Syndrome and significant proteinuria (\text{UPCR} \ge 0.8 \text{ g/g}) despite being on standard-of-care ACE inhibitors or ARBs. • Regimen: Randomized 2:1 to receive either setanaxib (1200 mg or 1600 mg daily based on age) or a placebo for 24 weeks. • Mechanism: Setanaxib targets NOX1 and NOX4 enzymes, which produce reactive oxygen species (ROS) that drive the glomerular scarring and podocyte damage characteristic of Alport syndrome. Conclusion The investigators concluded that setanaxib has an acceptable safety profile and shows a clinically meaningful trend toward reducing proteinuria in Alport syndrome patients. These results support further investigation in a larger, Phase 3 clinical trial.