@misc{10481/99835,
year = {2014},
month = {4},
url = {https://hdl.handle.net/10481/99835},
abstract = {Objective: This paper analyzes the fast and slow mechanisms of adaptation through a study of latencies and amplitudes on ABR recorded at high stimulation rates using the randomized stimulation and averaging (RSA) technique.

Methods: The RSA technique allows a separate processing of auditory responses, and is used, in this study, to categorize responses according to the interstimulus interval (ISI) of their preceding stimulus. The fast and slow mechanisms of adaptation are analyzed by the separated responses methodology, whose underlying principles and mathematical basis are described in detail.

Results: The morphology of the ABR is influenced by both fast and slow mechanisms of adaptation. These results are consistent with previous animal studies based on spike rate. 

Conclusions: Both fast and slow mechanisms of adaptation are present in all subjects. In addition, the distribution of the jitter and the sequencing of the stimuli may be critical parameters when obtaining reliable ABRs.

Significance: The separated responses methodology enables for the first time the analysis of the fast and slow mechanisms of adaptation in ABR obtained at stimulation rates greater than 100 Hz. The non-invasive nature of this methodology is appropriate for its use in humans.},
organization = {TEC2009-14245 project grant, funded by R&D National Plan (2008–2011), Ministry of
Economy and Competivity (Government of Spain) and European
Regional Development Fund Programme (2007–2013)},
organization = {‘‘Programa de Formación de Profesorado Universitario (FPU)’’ (AP2009-3150) fellowship, funded by Ministry of Education, Culture, and Sports (Government of Spain)},
publisher = {Clinical Neurophysiology, Elsevier Ireland LTD},
title = {A study of adaptation mechanisms based on ABR recorded at high stimulation rate},
doi = {10.1016/j.clinph.2013.06.190},
author = {Valderrama Valenzuela, Joaquín Tomás and Torre Vega, Ángel De La and Ruiz Álvarez, Isaac Manuel and Segura Luna, José Carlos and Thornton, Arthur Roger David and Sainz Quevedo, Manuel and Vargas, Jose L},
}