@misc{10481/99635,
year = {2004},
url = {https://hdl.handle.net/10481/99635},
abstract = {Purpose : To study the correlation between the expression of integrin fractions and adhesion molecules on granulosa cells (GC) and follicular development.

Methods : GC and follicular fluid (FF) were obtained at oocyte retrieval for ICSI. Expression of adhesion molecules on GC was studied by flow cytometry. Statistics were evaluated using the Student t test and simple linear regression analysis.

Results : α5 integrin fraction was significantly (p<0.01) higher, while α6 fraction and CD9 were significantly (p<0.01 and p<0.001, respectively) lower in GC from FF with metaphase II oocytes. A direct significant correlation was observed between FF progesterone and the α5 expression on GC (r=0.54). In contrast, an inverse significant correlation was observed between FF progesterone level and the expression of α6 and CD9 (r= −0.40 and −0.41, respectively).

Conclusions : The expression pattern for integrin fractions and adhesion molecules may be of predictive value in assessing the state of differentiation of the human follicle.},
publisher = {Springer Nature},
keywords = {Adhesion},
keywords = {flow cytometry},
keywords = {granulosa},
keywords = {integrin},
keywords = {steroidogenesis},
title = {Expression of integrin fraction and adhesion molecules on human granulosa cells and its relation with oocyte maturity and follicular steroidogenesis},
doi = {10.1023/b:jarg.0000040233.32946.60},
author = {Clavero, A. and Castilla, José A. and Martínez, L. and Mendoza, N. and Fontes, J. and Maldonado, V.},
}