@misc{10481/99602,
year = {1999},
url = {https://hdl.handle.net/10481/99602},
abstract = {The risk of developing breast cancer is higher in women presenting gross cystic disease (cysts > 3mm in diameter)
of the breast with intracystic KC/NaC > 3 as compared with KC/NaC < 3. The present study reports the
levels of tumour necrosis factor-a (TNF-a), interleukin-1 (IL-1), and interleukin-6 (IL-6) in the breast cyst fluid
of women with gross cystic disease and analyses the relationship between the intracystic concentration of these
cytokines, sex steroid hormones, and theKC/NaCratio. The concentration of these cytokines, estradiol, testosterone,
dehydroepiandrosterone sulfate (DHEA-S), and 17-OH-progesterone were determined in the breast cyst fluid of
54 women with gross cystic disease. No significant differences were found in the cystic levels of IL-1 between
cysts with intracystic KC/NaC < 3 and > 3. However, in cysts with intracystic KC/NaC > 3 we found a lower
concentration of IL-6 and TNF-a than in those with intracystic KC/NaC < 3. Stepwise multiple linear regression
analysis demonstrated that the concentration of IL-6 in breast cyst fluid was predicted statistically by a negative
regression coefficient for the concentration of estradiol and DHEA-S, and by a positive regression coefficient for the
concentration of TNF-a. The concentration of TNF-a in breast cyst fluid was predicted statistically by a positive
regression coefficient for the concentration of IL-6, and by a negative regression coefficient for the concentration
of estradiol. No candidate variable was included in the model to predict concentrations of IL-1 in breast cyst fluid.
Our results indicate that IL-6 and TNF-a could have a local ‘protector’ role in gross cystic disease, and that they
could be used as a marker to identify cyst type.},
publisher = {Springer},
keywords = {breast cyst fluid},
keywords = {gross disease},
keywords = {IL-1},
keywords = {IL-6},
keywords = {TNF-a},
title = {Tumour necrosis factor‐α and interleukin‐1 and ‐6 in fibrocystic breast disease.},
doi = {10.1023/a:1006174931004},
author = {Herruzo, Alfonso and Castilla, Jose Antonio and Ramírez, Ángel and Marcos, Cristina and Menjón, Salomón},
}