@misc{10481/99490,
year = {2020},
month = {10},
url = {https://hdl.handle.net/10481/99490},
abstract = {Abstract
Objective The amygdala is importantly involved in stress and obesity, but its role on weight change and diet-related stress
remains unexplored among adolescents with excess weight. We aimed to examine the functional connectivity of the Central
and Basolateral amygdala nuclei (CeA and BLA) among adolescents, and to explore the longitudinal association between
brain connectivity measures and diet-related cortisol and weight loss in adolescents with excess weight.
Methods We compared resting-state functional connectivity between adolescents with excess (EW, N = 34; Age = 16.44 ±
1.66) and normal weight (NW, N = 36; Age = 16.50 ± 1.40) using a seed-based (CeA and BLA) whole-brain approach.
Then, in a subset of 30 adolescents with EW, followed-up after 3-months of dietary/lifestyle intervention, we explored for
interactions between connectivity in the CeA/BLA networks and weight loss. Regression analyses were performed to
explore the relationship between accumulated cortisol and weight loss, and to test the potential effect of the amygdala
networks on such association.
Results In EW compared with NW, the CeA regions showed higher functional connectivity with anterior portions, and
lower connectivity with posterior portions of the cingulate cortex, while the left BLA regions showed lower connectivity
with the dorsal caudate and angular gyrus. In addition, higher connectivity between the left CeA-midbrain network was
negatively associated with weight loss. Hair cortisol significantly predicted weight change (p = 0.012). However, this
association was no longer significant (p = 0.164) when considering the CeA-midbrain network in the model as an additional
predictor.
Conclusions Adolescents with EW showed functional connectivity alterations within the BLA/CeA networks. The CeAmidbrain
network might constitute an important brain pathway regulating weight change.},
organization = {Project NEUROECOBE - Andalusian Council of Innovation, Science and Industry, Spain HUM-6635	
Health Department of the Catalan Government, Spain SLT006/17/00236	
Spanish Government FJCI-2017-33396	
Medical Research Future Fund (MRFF) MRF1141214	
National Health & Medical Research Council (NHMRC) of Australia GNT1140197},
publisher = {Springer Nature},
title = {Stressing diets? Amygdala networks, cumulative cortisol, and weight loss in adolescents with excess weight},
doi = {10.1038/s41366-020-0633-4},
author = {Verdejo García, Antonio Javier and González Pérez, Raquel and Vilar López, Raquel and Verdejo Román, Juan and Contreras Rodríguez, Oren and Martín-Pérez, Cristina},
}