@misc{10481/99329,
year = {2011},
url = {https://hdl.handle.net/10481/99329},
abstract = {Studies of human systemic lupus erythematosus patients and of murine congenic mouse
strains associate genes in a DNA segment on chromosome 1 with a genetic predisposition
for this disease. The systematic analysis of lupus-prone congenic mouse strains suggests a
role for two isoforms of the Ly108 receptor in the pathogenesis of the disease. In this
study, we demonstrate that Ly108 is involved in the pathogenesis of lupus-related autoimmunity
in mice. More importantly, we identified a third protein isoform, Ly108-H1,
which is absent in two lupus-prone congenic animals. Introduction of an Ly108-H1–
expressing transgene markedly diminishes T cell–dependent autoimmunity in congenic
B6.Sle1b mice. Thus, an immune response–suppressing isoform of Ly108 can regulate the
pathogenesis of lupus.},
title = {A novel isoform of the Ly108 gene ameliorates murine lupus},
author = {Keszei, Marton and Detre, Cynthia and Rietdijk, Svend and Muñoz Fernández, Pilar and Romero, Xavier and Berger, Scott B and Calpe, Silvia and Liao, Gongxian and Castro, Wilson and Julien, Aimee and Wu, Ying-Yu and Shin, Dong-Mi and Sancho, Jaime and Zubiaur, Mercedes and Herbert C. Morse III and Morel, Laurence and Engel, Pablo and Wang, Ninghai and Terhorst, Cox},
}