@misc{10481/99230,
year = {2025},
month = {1},
url = {https://hdl.handle.net/10481/99230},
abstract = {Background Perinatal growth and nutrition have been shown to be determinants in the programming of different
tissues, such as adipose tissue, predisposing individuals to metabolic alterations later in life. Previous studies have
documented an increased risk of metabolic disturbances and low-grade inflammation in prepubertal children with a
history of extrauterine growth restriction (EUGR). The aim of this study was to evaluate possible alterations resulting
from impaired growth during early childhood and their impact on young adult health.
Methods This is a longitudinal, descriptive and analytical study of a cohort with a history of EUGR recruited at
prepubertal age and followed up for 10 years until the end of puberty. Anthropometric measurements, blood
pressure, biochemical parameters related to lipid and carbohydrate metabolism and plasma adipokines and cytokines
were analyzed.
Results Compared with prepubertal children, young adults EUGR presented increased abdominal circumference
percentiles. Moreover, insulin levels and the homeostatic model assessment for insulin resistance (HOMA-IR) index
were higher in young adults, with a considerable proportion of participants (22%) becoming insulin-resistant after
pubertal development. In contrast, arterial hypertension was observed in 36% of prepubertal children compared
with 18% of postpubertal young adults. Lipid values were within normal ranges without differences. Adiponectin and
leptin remained at similar levels in adulthood, with a decrease in resistin.
Conclusion Individuals with a history of EUGR have increased metabolic risk in adulthood, which emphasizes the
importance of clinical follow-up from childhood to prevent the development of further future associated diseases.},
organization = {Modalidad Retos Consolidado. Dirección
General de Investigación y Transferencia del Conocimiento. Consejería de
Economía, Conocimiento, Empresas y Universidad. Junta de Andalucía, Spain
(grant number PY18-1802)},
organization = {SPAOYEX
research grant 2022 edition},
publisher = {Palomino Fernández, L. et. al.  J Transl Med 23, 67 (2025). [https://doi.org/10.1186/s12967-024-06053-2]},
keywords = {Adipokines},
keywords = {Extrauterine growth restriction},
keywords = {Inflammation},
title = {Metabolic and inflammatory status in prepuberty and early adulthood for individuals with a history of extrauterine growth restriction: a cohort study},
doi = {10.1186/s12967-024-06053-2},
author = {Palomino-Fernández, Laura and Velasco, Inmaculada and Pastor Villaescusa, Belén and Flores Rojas, Katherine and de la Cruz Rico, María and Roa, Juan and Gil Hernández, Ángel and Gil-Campos, Mercedes},
}