@misc{10481/99197,
year = {2025},
month = {1},
url = {https://hdl.handle.net/10481/99197},
abstract = {The optimization of bioactive compound extraction from Fucus vesiculosus using
ultrasound-assisted extraction (UAE) via sonotrode was investigated to maximize
phenolic recovery and antioxidant activity while promoting a sustainable process. Optimal
conditions (40% v/v ethanol in water, 38 min, 36% amplitude) were selected to
maximize phenolic recovery while considering environmental and energy sustainability
by optimizing extraction efficiency and minimizing solvent and energy usage. HPLCESI-
QTOF-MS analysis tentatively identified 25 phenolic compounds, including sulfated
phenolic acids, phlorotannins, flavonoids, and halophenols, with some reported for the
first time in F. vesiculosus, underscoring the complexity of this alga’s metabolome. The
antioxidant activity of the optimized extract was evaluated through FRAP (143.7 μmol
TE/g), DPPH (EC50 105.6 μg/mL), and TEAC (189.1 μmol Trolox/g) assays. The optimized
process highlights F. vesiculosus as a valuable source of natural antioxidants, with potential
applications in biotechnology, cosmetics, and food industries.},
organization = {PRIMA program, under the BioProMedFood project
(“Bio-protective cultures and bioactive extracts as sustainable combined strategies to improve the
shelf-life of perishable Mediterranean food”; Project ID: 1467; Reference Number: 2019-SECTION2-4;
CUP: J34I19004820005)},
organization = {PRIMA program is supported by the European Union H2020 program
and innovation program},
publisher = {MDPI},
keywords = {brown seaweeds},
keywords = {Box–Behnken design},
keywords = {chlorophenols},
title = {Optimization of a Sonotrode Extraction Method and New Insight of Phenolic Composition of Fucus vesiculosus},
doi = {10.3390/md23010040},
author = {Gil-Martinez, Lidia and Santos Mejías, Alejandro and De la Torre Ramírez, José Manuel and Baños-Arjona, Alberto and Verardo, Vito and Gómez Caravaca, Ana María},
}