@misc{10481/98683,
year = {2024},
month = {3},
url = {https://hdl.handle.net/10481/98683},
abstract = {Transition-metal-catalyzed bioorthogonal reactions emerged a
decade ago as a novel strategy to implement spatiotemporal
control over enzymatic functions and pharmacological interventions.
The use of this methodology in experimental therapy
is driven by the ambition of improving the tolerability and PK
properties of clinically-used therapeutic agents. The preclinical
potential of bioorthogonal catalysis has been validated in vitro
and in vivo with the in situ generation of a broad range of
drugs, including cytotoxic agents, anti-inflammatory drugs and
anxiolytics. In this article, we report our investigations towards
the preparation of solid-supported Cu(I)-microdevices and their
application in bioorthogonal uncaging and click reactions. A
range of ligand-functionalized polymeric devices and off-on
Cu(I)-sensitive sensors were developed and tested under
conditions compatible with life. Last, we present a preliminary
exploration of their use for the synthesis of PROTACs through
CuAAC assembly of two heterofunctional mating units.},
organization = {European Union’s Horizon 2020
research and innovation program under the Marie Sklodowska-
Curie Grant Agreement no. 765497 (THERACAT)},
organization = {Horizon 2020 research and innovation programme under the
Marie Skłodowska Curie grant agreement No. 749299},
organization = {EPSRC (EP/N021134/1)},
publisher = {Wiley Online Library},
title = {Development of Biocompatible Cu(I)-Microdevices for Bioorthogonal Uncaging and Click Reactions},
doi = {10.1002/chem.202400611},
author = {Van de L’Isle, Melissa and Croke, Stephen and Valero Griñán, María Teresa and Unciti-Broceta, Asier},
}