@misc{10481/98542,
year = {2024},
month = {12},
url = {https://hdl.handle.net/10481/98542},
abstract = {Irritable bowel syndrome is a common functional gastrointestinal disorder characterized
by recurrent abdominal discomfort, bloating, cramping, flatulence, and changes in
bowel movements. The pathophysiology of IBS involves a complex interaction between motor,
sensory, microbiological, immunological, and psychological factors. Diversity, stability,
and metabolic activity of the gut microbiota are frequently altered in IBS, thus leading to a
situation of gut dysbiosis. Therefore, the use of probiotics and probiotic-derived metabolites
may be helpful in balancing the gut microbiota and alleviating irritable bowel syndrome
symptoms. This review aimed to report and consolidate recent progress in understanding
the role of gut dysbiosis in the pathophysiology of IBS, as well as the current studies that
have focused on the use of probiotics and their metabolites, providing a foundation for
their potential beneficial effects as a complementary and alternative therapeutic strategy
for this condition due to the current absence of effective and safe treatments.},
organization = {Junta de Andalucía (CTS 164), the Instituto de Salud Carlos
III (Spain), the Ministerio de Ciencia e Innovación (Spain), and the Fondo Europeo de Desarrollo
Regional (FEDER) from the European Union through the research grants PI18/00826, PY20-01157,
PI20/01447, B-CTS-664-UGR20, PI19/01058, and JDC2022-049478-I},
publisher = {MDPI},
keywords = {Irritable bowel syndrome},
keywords = {gastrointestinal},
keywords = {treatment},
title = {Exploring Gut Microbiota Imbalance in Irritable Bowel Syndrome: Potential Therapeutic Effects of Probiotics and Their Metabolites},
doi = {10.3390/nu17010155},
author = {García Mansilla, María José and Rodríguez Sojo, María Jesús and Roxana Lista, Andrea and Ayala Mosqueda, Ciskey Vanessa and Ruiz Malagón, Antonio Jesús and Gálvez Peralta, Julio Juan and Rodríguez Nogales, Alba and Rodríguez Sánchez, María José},
}