@misc{10481/98518,
year = {2025},
month = {1},
url = {https://hdl.handle.net/10481/98518},
abstract = {Background: We sought to develop a structural equation model (SEM) identifying
physical and clinical risk factors associated with treatment for retinopathy of prematurity
(ROP). Methods: This retrospective, observational, case–control study included 314 infants
screened for ROP between April 2004 and July 2024. A bivariate binary logistic regression
model, decision tree, and structural equation model (SEM) were employed to develop
a more general model for ROP requiring treatment. Results: In the SEM, the factors
significantly associated with ROP treatment included the retinal avascular area according to
disk diameter (DD) (p < 0.001), weekly vascularisation rate (DD/w) (p < 0.001), and duration
of intubation (days) (p < 0.001). In addition, the following significant associations were
identified in both the bivariate analysis and the SEM: lower gestational age (p < 0.001) and
birth weight (p <0.001) were associated with greater retinal avascular area; low postnatal
weight gain (p < 0.027) was associated with a slow rate of retinal vascularisation; sepsis
(p < 0.001), ductus arteriosus (p < 0.001), and the need for transfusion (p < 0.001) were
associated with longer intubation mechanical ventilation (IMV). Conclusions: Lower
gestational age, lower birth weight, sepsis, ductus arteriosus, transfusion, and lower
weight gain increase the risk of requiring ROP treatment. In the SEM, this association is
represented through three intermediate physical endogenous variables, namely, the greater
temporal avascular area of the retina, the lower postnatal vascularisation rate, and the
greater duration of IMV.},
publisher = {MDPI},
keywords = {retinopathy of prematurity},
keywords = {therapy},
keywords = {structural equation models},
title = {Structural Equation Modelling of Retinopathy of Prematurity Treatment Integrating Both Physical and Clinical Effects},
doi = {10.3390/jcm14020297},
author = {García-Serrano, José Luis and Protsyk, Olena and Domech Serrano, Teresa and Uberos Fernández, José},
}