@misc{10481/98229,
year = {2016},
url = {https://hdl.handle.net/10481/98229},
abstract = {Objectives The aim was to determine whether clinical periodontal parameters are associated with plasma anti- and/or pro-inflammatory cytokines in pregnant woman with preterm birth (PB) or low birth weight (LBW) neonates. Materials and methods An observational case-control study was performed in 131 puerperal women: mothers of PB/LBW neonates (cases, n = 67) and mothers of full-term normal-weight neonates (controls, n = 64). Sociodemographic and periodontal data was gathered from all participants, and interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-17, IL-23, and tumor necrosis factor alpha (TNF-α) were determined in plasma. Results In multiple linear regression models, clinical attachment loss was associated with TNF-α (0.28 ± 0.14; 95 % confidence interval (CI) [0.006, 0.553]) and IL-1β (0.43 ± 0.21; 95 %CI [0.018, 0.842]), independent of group membership. IL-1β (−1.67 ± 0.27, 95 %CI [−2.199, −1.141]), IL-6 (−0.86 ± 0.27; 95 %CI [−1.389, −0.331]), and IL-8 (−3.84 ± 0.50, 95 %CI [−4.820, −2.860]) were lower, and IL-10 (0.86 ± 0.26; 95 %CI [0.350, 1.370]) was higher in cases versus controls after adjusting for potential confounders. Conclusions Clinical attachment loss was associated with plasma TNF-α and IL-1β levels. No plasma cytokine profiles suggestive of systemic inflammatory response were observed in the pregnant women with PB/LBW neonates. Clinical relevance Clinical attachment loss, as the main periodontal measure, is associated with TNF-α and IL-1β plasma levels in pregnant women. No relationship was found between PB/LBW and the markers of systemic inflammatory response assessed in this study.},
title = {Relationship between periodontal parameters and plasma cytokine profiles in pregnant woman with preterm birth or low birth weight},
doi = {10.1007/s00784-015-1553-x},
author = {Mesa Aguado, Francisco Luis and Pozo, Elena and O'Valle Ravassa, Francisco Javier and Puertas, Alberto and Magán Fernández, Antonio and Rosel Gallardo, Eva and Bravo Pérez, Manuel},
}