@misc{10481/97948,
year = {2024},
month = {12},
url = {https://hdl.handle.net/10481/97948},
abstract = {Background: Thyroglobulin (Tg) is the specific tumor marker for epithelial thyroid cancer.
It holds significant value in the postoperative period, and somehow, the goal of surgery in papillary
thyroid cancer (PTC) undergoing total thyroidectomy is to achieve undetectable levels of postoperative
thyroglobulin (uTg). Methods: This is a retrospective single-center study in which first basal Tg
values were evaluated post-surgery in PTC patients undergoing total thyroidectomy. Patients with
elevated antithyroglobulin antibodies were excluded. The impact of various demographic, clinical,
therapeutic, tumor-stage related, and histopathological variables on the achievement of undetectable
thyroglobulin levels (uTg, <1 ng/mL) was studied. A descriptive and logistic regression-based
bivariate and multivariate analysis was planned using STATA vs. 16.1. program. The significance
level was stated at 0.05. Results: Basal athyroglobulinemia was obtained in 89.6% of 202 patients
operated on between January 2015 and June 2023 in a single referral institution. Due to the limited
number of cases with detectable Tg, multivariate analysis could not be performed. The main
factors that favored its achievement on bivariate analysis were a smaller tumor size (p = 0.003), no
need for extended resections due to local invasion beyond the thyroid gland (p = 0.003) or neck
dissection (p = 0.039), absence of distant metastases (p = 0.000), and a lower MACIS score (p < 0.000).
Conclusions: The achievement of uTg was closely related to factors related to tumor stage (tumor
diameter, lymph node spread, and metastatic disease), and it was not influenced by differences in
epidemiological data, clinic manifestations, preoperative diagnosis, multifocality, or the presence of
aggressive cytological variants.},
publisher = {MDPI},
keywords = {athyroglobulinemia},
keywords = {thyroglobulin},
keywords = {papillary thyroid cancer},
title = {Predictive Factors of Athyroglobulinemia After Total Thyroidectomy for Papillary Thyroid Cancer},
doi = {10.3390/cancers16244129},
author = {Fernández Baeza, Marta and Muñoz Pérez, Nuria and Roldán Ortiz, Ignacio and Alonso Sebastián, María J. and Carbajo Barbosa, Francisco M. and Rejón López, Rafael and Olvera-Porcel, Maria Carmen and Becerra Massare, Antonio and Arcelus Martínez, Juan Ignacio and Villar Del Moral, Jesús María},
}