@misc{10481/97752,
year = {2024},
url = {https://hdl.handle.net/10481/97752},
abstract = {The challenges in biomimetics today include replicating complex functions of natural cells
in synthetic systems. Mimicking these functions, such as sensing/response mechanisms
or e cient chemical processing, in arti cial cells has great potential in applications such
as contaminant clean-up, clinical diagnosis, drug delivery, tissue synthesis, gene therapy,
etc. [1{4] In particular, bioinspired micro-compartments capable of life-like behaviours
such as encapsulation of biochemical reactions or selective exchange of compounds with
their environment can serve as micro-reactors for biosynthesis or energy conversion [5,6].
Equipping these micro-compartments with mechanisms suitable for exploiting force
 elds as energy sources would be especially interesting, as force  elds o er high levels of
spatio-temporal control and versatility, as well as the possibility of acting remotely and
reversibly. In particular, electromagnetic force  elds constitute an attractive technique for
remote manipulation, which would allow  ne-grained control of performance, orientation,
mixing or content transfer in micro-reactors [7]. Within electromagnetic  elds, the use of
magnetic  elds is particularly noteworthy due to their simplicity, precision, versatility and
low cost [8]. Thanks to bottom-up approaches, micro-compartments responsive to these
 elds can be constructed using magnetic  eld-sensitive nanoparticles as building blocks
of the micro-compartment architecture. Magnetic  eld-sensitive micro-compartments
have shown complex behaviors, such as motility and phagocytosis [9, 10].
The starting hypothesis of this PhD thesis is the possibility of remotely, precisely and
dynamically manipulating bioinspired micro-compartments through the use of external
force  elds. In the particular case of arti cial cell-inspired micro-reactors, we hypothesise
that external force  elds could be harnessed to control their orientation, spatial
arrangement, mixing and transfer of contents, reaction rate, etc. Furthermore, the use
of external force  elds would allow the manipulation of multiple compartments at the
same time, making it possible to study collective and dynamic behaviour in micro-reactor
populations. Despite these encouraging expectations, research on micro-compartments
controllable by force  elds is scarce. Thus, the exploration of new approaches and their
optimisation is still necessary to establish useful, e cient and fruitful methodologies.},
organization = {Tesis Univ. Granada.},
organization = {Grant PID2019-105930GA-I00, funded by MCIN/AEI/10.13039/501100011033, Spanish Ministry of Science and Innovation (2019)},
organization = {Grant A-FQM-258-UGR20, ERDF funds, Junta de Andalucía, University of Granada (2020)},
publisher = {Universidad de Granada},
title = {Activación externa de micro-reactores inspirados en células artificiales mediante campos de fuerza},
author = {Escribano Huesca, Alfredo},
}