@misc{10481/97522,
year = {2024},
month = {11},
url = {https://hdl.handle.net/10481/97522},
abstract = {Olive mills produce pomace as a by-product of olive oil production process, which has a
negative environmental impact. In this study, the dry extract of pomace (OG2), rich in polyphenols,
was used for cosmetic purposes. The polyphenolic extract was encapsulated together with sholigopeptide-
1 using cellulose fibres by spray-drying technology. Cytotoxicity and antistress cell
studies were carried out using a modified cell line (THP1). Based on the results, a single, randomised,
self-controlled study was conducted to evaluate the cream in thirty healthy volunteers. Statistical
analysis was performed using a paired samples t-test. Skin moisture increased in the treated forearm
(p-value < 0.000). There was an increase in elasticity in the treated forearm (p-value 0.042). TEWL
decreased after one week of cream application (p-value 0.099). The results of this clinical study
showed that the cream improved barrier function after one week of application on healthy skin.},
organization = {Instituto de Investigación Biotecnológica, Farmacéutica
y Medicamentos Huérfanos, S.L},
organization = {Centre for the Development of Industrial
Technology (Spain), Program FEDER INTERCONECTA (ITC-20181113)},
publisher = {MDPI},
keywords = {upcycling},
keywords = {polyphenols},
keywords = {sh-oligopeptide-1},
title = {Microencapsulation, Cream Development, and Controlled Clinical Study of an Upcycled Polyphenolic Extract Combined with sh-Oligopeptide-1},
doi = {10.3390/cosmetics11060198},
author = {Mayayo, Teo and Russo, Gabriella and Jiménez-Escobar, Ana Leticia and Pérez González, Noelia and Clares Naveros, Beatriz and Ruiz Martínez, Adolfina and Tomás-Cobos, Lidia and Valera, Ana and Gómez-Farto, Almudena and Arias Santiago, Salvador and Montero Vílchez, Trinidad},
}