@misc{10481/97487,
year = {2024},
month = {11},
url = {https://hdl.handle.net/10481/97487},
abstract = {Background Despite extensive research, the effects of conjugated linoleic acid (CLA)
supplementation in treating obesity are still unclear and equivocal. Adipokines play an
important regulatory role in the activation of adipose tissue function. The purpose of
the present research is to investigate the efficacy of CLA supplementation during highintensity
interval training (HIIT) on plasma neuregulin 4 (NRG-4), interleukin 6 (IL-6),
and tumor necrosis factor α (TNF-α) in obese men.
Methodology Forty-four nonactive, obese males (age¼26.29 0.97 y, body mass
index [BMI]¼32.29 1.27 kg/m2) participated in this research. Participants were
randomly divided into four groups: control, without training or CLA supplementation;
supplement, CLA supplementation without training; exercise, HIIT without CLA
supplementation; supplementþexercise, HIIT with CLA supplementation. HIIT was
performed for 12 weeks, three sessions per week, with a training intensity ranging from
60 to 75% of the VO2 max on a treadmill. Subjects in the CLA supplement groups
consumed two 1-g CLA capsules daily in two meals with breakfast and dinner. The
amount of plasma NRG-4, IL-6, and TNF-α was measured using an ELISA (enzyme-linked
immunosorbent assay) kit. Various variables were collected at two time points (pretest
and posttest).
Results The study found that both the HIIT and HIITþCLA groups showed greater
improvements in weight and BMI compared with the other groups. Notably, posttest
levels of NRG-4 were significantly higher in the CLA, HIIT, and HIITþCLA groups
compared with the control group (p<0.001). Additionally, following the intervention period, IL-6 levels in the HIITþCLA group and TNF-α levels in the HIIT and HIITþCLA
groups were significantly lower than in the control group (p<0.001).
Conclusion CLA supplementation, in conjunction with HIIT, emerges as a highly
effective approach and more benefits on the amount of adipokines secreted from fat
tissue in obese people than either of them separately.},
publisher = {Thieme Gruppe},
keywords = {conjugated linoleic acid},
keywords = {immune functions},
keywords = {therapeutic window},
title = {The Effect of CLA Supplementation and High- Intensity Interval Training on Plasma Neuregulin 4, Interleukin 6, and TNF-α in Obese Men},
doi = {10.1055/s-0044-1791966},
author = {Abbassi-Daloii, Asieh and Barari, Alireza and Bolboli, Niloufar and Saeidi, Ayoub and Zahabi, Ghadir and García Ramos, Amador and Ilic, Vladimir and Nedeljkovic, Aleksandar},
}