@misc{10481/97457,
year = {2024},
month = {1},
url = {https://hdl.handle.net/10481/97457},
abstract = {Objective
The study objective was to investigate the effect of cold exposure on the plasma levels of five potential human brown adipokines (chemokine ligand 14 [CXCL14], growth differentiation factor 15 [GDF15], fibroblast growth factor 21 [FGF21], interleukin 6 [IL6], and bone morphogenic protein 8b [BMP8b]) and to study whether such cold-induced effects are related to brown adipose tissue (BAT) volume, activity, or radiodensity in young humans.

Methods
Plasma levels of brown adipokines were measured before and 1 h and 2 h after starting an individualized cold exposure in 30 young adults (60% women, 21.9 ± 2.3 y; 24.9 ± 5.1 kg/m2). BAT volume, 18F-fluorodeoxyglucose uptake, and radiodensity were assessed by a static positron emission tomography-computerized tomography scan after cold exposure.

Results
Cold exposure increased the concentration of CXCL14 (Δ2h = 0.58 ± 0.98 ng/mL; p = 0.007), GDF15 (Δ2h = 19.63 ± 46.2 pg/mL; p = 0.013), FGF21 (Δ2h = 33.72 ± 55.13 pg/mL; p = 0.003), and IL6 (Δ1h = 1.98 ± 3.56 pg/mL; p = 0.048) and reduced BMP8b (Δ2h = −37.12 ± 83.53 pg/mL; p = 0.022). The cold-induced increase in plasma FGF21 was positively associated with BAT volume (Δ2h: β = 0.456; R2 = 0.307; p = 0.001), but not with 18F-fluorodeoxyglucose uptake or radiodensity. None of the changes in the other studied brown adipokines was related to BAT volume, activity, or radiodensity.

Conclusions
Cold exposure modulates plasma levels of several potential brown adipokines in humans, whereas only cold-induced changes in FGF21 levels are associated with BAT volume. These findings suggest that human BAT might contribute to the circulatory pool of FGF21.},
organization = {Agencia Estatal de Investigaci on, Grant/Award Number: DEP2016- 79512-R},
organization = {AstraZeneca HealthCare Foundation},
organization = {Fundación Alfonso Martin Escudero},
organization = {Spanish Ministry of Economy and Competitiveness via Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393)},
organization = {PTA 12264-I, Retos de la Sociedad (DEP2016-79512-R)},
organization = {European Regional Development Funds (ERDF), by the Spanish Ministry of Education (FPU13/04365, FPU16/02828, FPU16/03653)},
organization = {Redes Temáticas De Investigación Cooperativa RETIC (Red SAMID RD16/0022)},
organization = {University of Granada Plan Propio de Investigación 2016-Excellence actions: Unit of Excellence on Exercise and Health (UCEES)},
organization = {University of Granada Plan Propio de Investigación 2018-Contrato Perfeccionamiento de Doctores},
organization = {Plan de Resilencia UGR: Ayudas Margarita Salas},
organization = {Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (ERDF, SOMM17/6107/UGR)},
organization = {Consejería de Economía, Conocimiento, Empresas y Universidad (P18-RT-4455)},
organization = {Universidad de Granada / CBUA},
publisher = {Wiley},
title = {Cold exposure modulates potential brown adipokines in humans, but only FGF21 is associated with brown adipose tissue volume},
doi = {10.1002/oby.23970},
author = {Méndez Gutiérrez, Andrea and Aguilera García, Concepción María and Cereijo, Rubén and Osuna Prieto, Francisco Javier and Martínez Téllez, Borja Manuel and Rico, María C. and Sánchez Infantes, David and Villarroya, Francesc and Ruiz Ruiz, Jonatan and Sánchez Delgado, Guillermo},
}