@misc{10481/97415,
year = {2020},
month = {2},
url = {https://hdl.handle.net/10481/97415},
abstract = {Introduction: Preventable risk factors for chronic lymphocytic leukemia (CLL) remain largely unknown. The aim of this study was to evaluate the association between adherence to nutrition-based guidelines for cancer prevention and CLL, in the MCC-Spain case–control study. Methods: A total of 318 CLL cases and 1293 population-based controls were included in the present study. The World Cancer Research Fund/American Institute for Cancer Research (WCRC/AICR) score based on the 2018 recommendations for cancer prevention (on body fatness, physical activity, and diet) was constructed. We used logistic regression analysis adjusting for potential confounders. Results: Individuals in the highest tertile of the WCRF/AICR score had an odds ratio for CLL of 1.25 (95 % CI 0.91; 1.73) compared with individuals with low adherence (p-trend = 0.172). Each point increment in the score was associated with an OR for CLL of 1.06 (95 % CI 0.91; 1.23). Analyses by severity of disease did not show significant heterogeneity of effects. Conclusion: Overall, our results do not support an association between the WCRF/AICR score and CLL, yet we might have been limited by statistical power and study design to detect modest associations. Further research, ideally with a prospective design, long follow-up, and including additional lymphoma subtypes, is warranted to confirm the impact of composite healthy lifestyle behaviors on lymphoma risk.},
organization = {Spanish Ministry of Economy and Competitiveness: Juan de la Cierva de Incorporación IJCI-2014-20900, Carlos III Institute of Health},
organization = {FEDER PI17/01280, PI11/01810, PI14/01219, PI11/02213, PI09/1662, PI15/00966, RCESP C03/09, RTICESP C03/10, RTIC RD06/0020/0095, RD12/0036/0056, SV-09-CLINIC-1 and CIBERESP},
organization = {Generalitat de Catalunya 2017SGR1085},
organization = {Spanish Ministerio de Economía y Competitividad (MINECO) PMP15/00007, CIBERONC},
publisher = {Elsevier},
keywords = {Chronic lymphocytic leukemia},
keywords = {WCRF/AICR 2018 recommendations},
keywords = {Nutrition-based guidelines},
keywords = {Case-control study},
title = {Adherence to the 2018 WCRF/AICR cancer prevention guidelines and chronic lymphocytic leukemia in the MCC-Spain study},
doi = {10.1016/j.canep.2019.101629},
author = {Solans, Marta and Romaguera, Dora and Gracia-Lavedan, Esther and Molinuevo, Amaia and Benavente, Yolanda and Saez, Marc and Marcos-Gragera, Rafael and Costas, Laura and Robles, Claudia and Alonso, Esther and De la Banda, Esmeralda and Gonzalez-Barca, Eva and Llorca, Javier and Rodríguez-Suarez, Marta María and Lozano Lorca, Macarena and Aymerich, Marta and Campo, Elias and Gimeno-Vázquez, Eva and Castaño-Vinyals, Gemma and Aragonés, Nuria and Pollán, Marina and Kogevinas, Manolis and De Sanjose, Silvia and Amiano, Pilar and Casabonne, Delphine},
}