@misc{10481/97413,
year = {2022},
month = {4},
url = {https://hdl.handle.net/10481/97413},
abstract = {Background: The etiology of prostate cancer (PCa) is not well-known, and the role of diet is not well established.
We aimed to evaluate the role of the inflammatory power of the diet, measured by Dietary Inflammatory Index (DII®),
on the risk of PCa.
Methodology: A population-based multicase-control (MCC-Spain) study was conducted. Information was collected
on sociodemographic characteristics, personal and family antecedents, and lifestyles, including diet from a Food
Frequency Questionnaire. The inflammatory potential of the diet was assessed using the energy-adjusted Dietary
Inflammatory Index (E-DII) based on 30 parameters (a higher score indicates a higher inflammatory capacity of the
diet). Tertiles of E-DII were created using the cut-off points from the control group. The International Society of
Urology Pathology (ISUP) was grouped as ISUP 1, ISUP 2, or ISUP 3-5). Unconditional logistic regression models
were used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for the association between E-
DII and PCa risk.
Results: A total of 928 PCa cases and 1278 population controls were included. Among PCa cases, the mean value of
the E-DII score was 0.18 (SD: 1.9) vs. 0.07 (SD: 1.9) in the control group (p=0.162). Cases with a more pro-
inflammatory diet (3rd tertile) had the highest risk of PCa, aORT3vsT1=1.30 (95% CI 1.03–1.65) (p-trend=0.026). When
stratifying by ISUP, this risk association is only maintained for ISUP 2 and ISUP 3-5, aORT3vsT1=1.46 (95% CI 1.02–
2.10) and 1.60 (95% CI 1.10–2.34), respectively
Conclusion: A positive association was observed between consuming a pro-inflammatory diet and PCa in the MCC-
Spain population, specifically for an ISUP grade greater or equal than 2.},
title = {Dietary inflammatory index and prostate cancer risk: MCC-Spain study},
doi = {10.1038/s41391-022-00532-7},
author = {Lozano Lorca, Macarena and Salcedo Bellido, Inmaculada and Olmedo Requena, María Rocío and Castaño-Vinyals, Gemma and Amiano, Pilar and Shivappa, Nitin and Hébert, James R. and Pérez-Gómez, Beatriz and Gracia-Lavedan, Esther and Gómez-Acebo, Inés and Molina-Barceló, Ana and Barrios Rodríguez, Rocío and Alguacil, Juan and Fernández-Tardón, Guillermo and Aragonés, Nuria and Dierssen-Sotos, Trinidad and Romaguera, Dora and Pollán, Marina and Kogevinas, Manolis and Jiménez Moleón, José Juan},
}