@misc{10481/97205,
year = {2024},
month = {7},
url = {https://hdl.handle.net/10481/97205},
abstract = {Adopting a risk assessment paradigm that is contextualized and strain-specific
will be critical to enabling the continued development and safe use of microbes,
particularly bacteria, in numerous industries and applications. An overly simplistic
approach of labeling bacterial species as either harmful or beneficial is ill-suited
for the complexities of their interactions with hosts and other microbes, where
the lines between friend, foe, and innocent bystander are often unclear. Many
such nuanced relationships have been described in human microbiome studies,
illustrating the inherent challenges of defining bacterial safety. Any effective risk
assessment framework must take into account bacterial niche and environment,
fitness, host health, route and extent of exposure, and strain characterization.
Klebsiella variicola, a diazotrophic soil bacterium isolated around the world, has
been the subject of increasing interest on both environmental and clinical fronts,
and has been used commercially as a biofertilizer on millions of farm acres. Here
we review its population structure, relevance in clinical and environmental
settings, and use as a biofertilizer in light of the risk assessment framework
described.},
publisher = {Frontiers Media},
keywords = {safety assessment},
keywords = {commensal microbiota},
keywords = {biotechnology},
title = {A paradigm for the contextual safety assessment of agricultural microbes: a closer look at Klebsiella variicola},
doi = {10.3389/finmi.2024.1412302},
author = {Marian, Christina and Sanjar, Fatemeh and Maxwell, Carl and Sabitu, Folashade and Hubbard, Natalie and Ratib, Nicole and Bojkov Vassilev, Nikolay and Sansinenea, Estibaliz},
}