@misc{10481/97056,
year = {2024},
month = {11},
url = {https://hdl.handle.net/10481/97056},
abstract = {Background/Objectives: This study aims to investigate the association of movement
behaviors with irisin, sclerostin, and bone turnover markers in young pediatric cancer survivors.
Methods: A total of 116 young pediatric cancer survivors (12.1 ± 3.3 years; 42% female) were
recruited. Time spent in movement behaviors over at least seven consecutive 24 h periods was
measured by accelerometers (wGT3x-BT accelerometer, ActiGraph). Blood samples were collected at
rest and serum was analyzed for irisin, sclerostin, cross-linked telopeptide of type I collagen (CTX),
procollagen type I amino-terminal propeptide (P1NP), total osteocalcin (OC), alkaline phosphatase
(ALP), 25-hydroxyvitamin D, parathyroid hormone (PTH), calcium, phosphorous, and magnesium.
Results: Irisin and sclerostin were not significantly correlated with bone turnover markers. Sedentary
time was negatively correlated with the P1NP (r = −0.411, p = 0.027) and total OC (r = −0.479,
p = 0.015) Z-scores, whereas moderate-to-vigorous physical activity was positively correlated with the
P1NP (r = 0.418, p = 0.024) and total OC (r = 0.478, p = 0.016) Z-scores. Moreover, total physical activity
was positively correlated with the total OC Z-score (r = 0.448, p = 0.025). Finally, the uncoupling
index [CTX/P1NP] was positively correlated with sedentary time (r = 0.424, p = 0.012) and negatively
correlated with light physical activity (r = −0.352, 0.041). Conclusions: Reducing sedentary time
and increasing physical activity may favor bone formation over resorption in young pediatric
cancer survivors.},
organization = {iBoneFIT project was funded by Ministerio de Ciencia e Innovación: PID2020-
117302RA-I00},
organization = {La Caixa Foundation: LCF/BQ/PR19/11700007},
organization = {Spanish Ministry of Universities (CAS22/00255)},
organization = {RYC2022-038011-I funding by
MCIN/AEI/10.13039/501100011033 and ESF+},
organization = {Predoctoral fellowship
(FPU20/05530) by the Spanish Ministry of Education, Culture and Sport},
publisher = {MDPI},
keywords = {bone turnover},
keywords = {exercise},
keywords = {children},
title = {Movement Behaviors and Bone Biomarkers in Young Pediatric Cancer Survivors: A Cross-Sectional Analysis of the iBoneFIT Project},
doi = {10.3390/nu16223914},
author = {Gil Cosano, José Juan and Ubago Guisado, Esther and Llorente Cantarero, Francisco Jesús and Mármol Pérez, Andrés and Rodríguez Solana, Andrea and Pascual Gázquez, Juan Francisco and Mateos, Maria E. and Molina-Hurtado, Jose R. and García Fontana, Beatriz and Narciso, Pedro Henrique and Klentrou, Panagiota and Gracia-Marco, Luis},
}