@misc{10481/96647,
year = {2021},
month = {8},
url = {https://hdl.handle.net/10481/96647},
abstract = {Adipose tissue has been recently highlighted as a promising matrix for evaluation of cadmium's (Cd) long-term exposure although not frequently considered in epidemiological studies. The association between Cd exposure and type 2 Diabetes Mellitus (T2DM) remains unclear. This work aimed to explore the association between adipose tissue Cd levels and T2DM incidence over a 16-year follow-up in an adult cohort from Southern Spain considering smoking status. We also performed complementary cross-sectional analyses focused on subclinical markers of glucose homeostasis at recruitment. Clinical information was obtained from hospital databases. Socio-demographic characteristics, lifestyle and diet were collected by face-to-face interviews. Homeostatic model assessment (HOMA) values of insulin sensitivity/resistance and β-cell function were calculated using fasting serum glucose, insulin, and C-peptide levels at recruitment. Adipose tissue Cd concentrations were quantified by inductively coupled plasma mass spectrometry. Statistical analyses were performed by means of Cox-regression and multivariable linear regression models. Participants in the 4th quartile (Q4) of Cd concentrations showed a non statistically-significant increased T2DM risk (Hazard Ratio (HR) Q4 vs Q1: 1.97; 95% Confidence Interval (CI): 0.69, 5.66). This association was particularly strong and suggestive in current smokers (HR: 2.19; 95% CI: 0.98, 4.98). Interestingly, smokers in the 2nd tertile (T2) of adipose tissue Cd levels showed increased log-transformed insulin resistance (beta T2 vs T1: 0.52; 95% CI: 0.07, 0.97), as well as higher log-transformed insulin levels (beta T2 vs T1: 0.52; 95% CI: 0.08, 0.95). We found evidences supporting that Cd exposure, particularly from tobacco smoking, could be a risk factor for T2DM. In addition, our results support the potential relevance of adipose tissue as a matrix for Cd exposure assessment.},
organization = {CIBER de Epidemiología y Salud Pública (CIBERESP)},
organization = {Instituto de Salud Carlos III},
organization = {European Regional Development Fun-FEDER (PI16/01858, PI20/01568, PI18/01573)},
organization = {Ministry of Higher Education, Science and Technology of the Republic of Slovenia (P2-0273)},
organization = {Ministerio de Economía, Industria y Competitividad, Spain) RYC-2016-20155},
publisher = {Elsevier},
title = {Adipose tissue cadmium concentrations as a potential risk factor for insulin resistance and future type 2 diabetes mellitus in GraMo adult cohort},
doi = {10.1016/j.scitotenv.2021.146359},
author = {Salcedo Bellido, Inmaculada and Gómez‑Peña, Celia and Pérez Carrascosa, Francisco Miguel and Vrhovnik, Petra and Mustieles Miralles, Vicente and Echeverría, Ruth and Fiket, Željka and Pérez-Díaz, Celia and Barrios Rodríguez, Rocío and Jiménez Moleón, José Juan and Arrebola Moreno, Juan Pedro},
}