@misc{10481/96552,
year = {2024},
month = {10},
url = {https://hdl.handle.net/10481/96552},
abstract = {Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease whose inci dence is increasing. Skin barrier dysfunction plays an important role in this disease. It has been
observed that AD patients have higher transepidermal water loss (TEWL) and lower stratum corneum
hydration (SCH); however, there is little information about skin microtopography in this pathology.
The objective of this study is to evaluate skin barrier dysfunction and structural changes in patients
with AD. Methods: A cross-sectional study was conducted including patients with AD. Parameters
of skin barrier function were measured (TEWL, temperature, erythema, pH, skin hydration, elasticity)
and also other topographical parameters (scaliness, wrinkles, smoothness, surface, contrast, variance)
in both healthy skin and flexural eczematous lesions. Results: A total of 32 patients with AD were
included in the study. Flexural eczematous lesions had higher erythema (369.12 arbitrary unit (AU)
vs. 223.89 AU, p < 0.001), higher TEWL (27.24 g/h/m2 vs. 13.51 g/h/m2
, p < 0.001), lower SCH
(20.3 AU vs. 31.88 AU, p < 0.001) and lower elasticity (0.56% vs. 0.65%, p = 0.05). Regarding topo graphic parameters, flexural eczematous lesions presented greater scaliness (5.57 SEsc vs. 0.29 SEsc,
p = 0.02), greater smoothness (316.98 SEsm vs. 220.95 SEsm p < 0.001), more wrinkles (73.33 SEw vs.
62.15 SEw p = 0.03), greater surface area (836.14% vs. 696.31%. p < 0.001), greater contrast (2.02 AU vs.
1.31 AU p = 0.01), greater variance (6.22 AU vs. 4.96 AU p < 0.001) and a lower number of cells (105.5
vs. 132.5 p < 0.001) compared to unaffected healthy skin, reflecting a decrease in skin quality in AD
patients. Conclusions: Both skin barrier function and skin topography are damaged in patients with
AD, with differences between healthy skin and flexural eczema.},
organization = {y Instituto de Salud Carlos III (ISCIII) through the project
PI23/01875},
organization = {postdoctoral fellowship from the ISCIII (CM22/00083) and
R.S.},
organization = {predoctoral fellowship from Ministry of Universities (FPU21/00833)},
publisher = {MDPI},
keywords = {atopic dermatitis},
keywords = {eczema},
keywords = {homeostasis},
title = {Skin Barrier Function and Microtopography in Patients with Atopic Dermatitis},
doi = {10.3390/jcm13195861},
author = {Pretel Lara, Carlota and Sanabria de la Torre, Raquel and Arias Santiago, Salvador and Montero Vílchez, Trinidad},
}