@misc{10481/96520,
year = {2016},
url = {https://hdl.handle.net/10481/96520},
abstract = {Abstract
Background: Virgin olive oil, a recognized healthy food, cannot be consumed in great quantities. We aim to assess
in humans whether an optimized virgin olive oil with high phenolic content (OVOO, 429 mg/Kg) and a functional
one (FOO), both rich in phenolic compounds (429 mg/Kg) and triterpenic acids (389 mg/kg), could provide health
benefits additional to those supplied a by a standard virgin olive oil (VOO).
Methods/design: A randomized, double-blind, crossover, controlled study will be conducted. Healthy volunteers
(aged 20 to 50) will be randomized into one of three groups of daily raw olive oil consumption: VOO, OVOO, and
FOO (30 mL/d). Olive oils will be administered over 3-week periods preceded by 2-week washout ones. The main
outcomes will be markers of lipid and DNA oxidation, inflammation, and vascular damage. A bioavailability and
dose-response study will be nested within this sustained- consumption one. It will be made up of 18 volunteers
and be performed at two stages after a single dose of each olive oil. Endothelial function and nitric oxide will be
assessed at baseline and at 4 h and 6 h after olive oil single dose ingestion.
Discussion: For the first time the NUTRAOLEUM Study will provide first level evidence on the health benefits
in vivo in humans of olive oil triterpenes (oleanolic and maslinic acid) in addition to their bioavailability and
disposition.
Trial registration: The Trial has been registered in ClinicalTrials.gov ID: NCT02520739.
Keywords: Olive oil, Virgin olive oil, Functional olive oil, Olive oil polyphenols, Maslinic acid, Oleanolic acid},
organization = {The NUTRAOLEOUM Study has been supported by the grant ITC-20131031
from the FEDER-INTERCONNECTA (CDTI) and Junta de Andalucía, Spain. We
thank ACER CAMPESTRES, San Francisco de Asis Coop. And., and AGROINSUR
SL, for providing the materials and processes for obtaining the olive oils used
in the Project. These sources do not have any rol or authority in the in study
design; collection, management, analyses, and interpretation of data; writing
or submission of the report},
publisher = {BIOMED CENTRAL LTD},
keywords = {olive oil},
keywords = {virgin olive oil},
keywords = {functional olive oil},
keywords = {Olive oil polyphenols},
keywords = {Maslinic acid},
keywords = {Oleanolic acid},
title = {The NUTRAOLEOUM Study, a randomized controlled trial, for achieving nutritional added value for olive oils},
doi = {10.1186/s12906-016-1376-6},
author = {Mesa García, María Dolores and Torre, Rafael de la and Biel Gibson, Sara and Espejo, Juan Antonio and Fernández Navarro, Juan Antonio and Fitó, Montserrat and Sánchez-Rodriguez, Estefanía and Rosa, Carmen and Marchal, Rosa and Alche, Juan de Dios and Expósito Ruiz, Manuela and Brenes, Manuel and Gandul, Beatriz and Calleja Hernández, Miguel Ángel and Covas, María Isabel},
}