@misc{10481/96428,
year = {2024},
month = {10},
url = {https://hdl.handle.net/10481/96428},
abstract = {Introduction Therapeutic burden (TB) has been identified as a potential predictor of
response to biologic therapy in hidradenitis suppurativa (HS). We aim to analyze the
determinants of TB in real-world clinical settings among HS patients to explain this concept
and its utility as an additional tool for guiding therapeutic decision-making.
Methods Weconducted a cross-sectional study including all consecutiveHSpatients
attending a specializedHSclinic between 2017 and 2024. The primary variable was TB, defined
as the cumulativesumof prior systemic treatment cycles and surgical interventions for HS.We
analyzed whether sociodemographic or clinical factors were associated with a higher TB.
Results We included 557 HS patients. Of these, 50.81% were women, and the mean age
was 41.87 (14.19) years. Most patients (62.30%) were referred from general dermatology
consultations. The mean disease duration was 17.52 (11.51) years. Regarding disease
severity, 46.50% presented with Hurley II, and 42.19% had an IHS-4 score between 4 and
10. Before their baseline visit, 9.70% of patients had received biological therapy, mostly
adalimumab (88.89%). The mean TB was 2.42 (2.25) systemic medical and/or surgical
interventions. Referral from general dermatology or other hospital departments, older age,
longer disease duration, greater HS severity, presence of pilonidal sinus, and prior
biological therapy were significantly associated with higher TB.
Conclusions Our findings suggest that TB comprehensively captures HS severity and
progression factors. This metric could prove valuable in aiding decision-making for HS
patients by indicating when a change in therapy might be necessary.},
publisher = {Wiley Online Library},
keywords = {hidradenitis suppurativa},
keywords = {therapeutic burden},
keywords = {treatment},
title = {Therapeutic burden in hidradenitis suppurativa: a crosssectional study of 557 patients},
doi = {10.1111/ijd.17517},
author = {Haselgruber, Sofía and Muñoz Barba, Daniel and León Pérez, Francisco Javier and Cuenca Barrales, Carlos and Arias Santiago, Salvador Antonio and Molina Leyva, Alejandro},
}