@misc{10481/96427,
year = {2024},
month = {9},
url = {https://hdl.handle.net/10481/96427},
abstract = {Macrophages are essential to muscle regeneration, as they regulate inflammation, carry
out phagocytosis, and facilitate tissue repair. These cells exhibit phenotypic switching from proinflammatory
(M1) to anti-inflammatory (M2) states during muscle repair, influencing myoblast
proliferation, differentiation, and myofiber formation. In Duchenne Muscular Dystrophy (DMD),
asynchronous muscle injuries disrupt the normal temporal stages of regeneration, leading to fibrosis
and failed regeneration. Altered macrophage activity is associated with DMD progression and
physiopathology. Gaining insight into the intricate relationship between macrophages and muscle
cells is crucial for creating effective therapies aimed at treating this muscle disorder. This review
explores the dynamic functions of macrophages in muscle regeneration and their implications
in DMD.},
organization = {Grants DUCHENNE_2018/001 (Duchenne Parent
Project, Spain Foundation)},
organization = {PID2022–138163OB-C31 (Ministerio de Ciencia e Innovación, Gobierno
de España)},
organization = {ProyExcel_00513 (Consejería de Universidad, Investigación e Innovación, Junta
de Andalucía)},
publisher = {MDPI},
keywords = {macrophages},
keywords = {inflammation},
keywords = {skeletal muscle},
title = {Macrophages in the Context of Muscle Regeneration and Duchenne Muscular Dystrophy},
doi = {10.3390/ijms251910393},
author = {Hernández Torres, Francisco and Matías Valiente, Lidia and Alzas-Gomez, Virginia and Eva Aranega, Amelia},
}