@misc{10481/95982,
year = {2024},
month = {9},
url = {https://hdl.handle.net/10481/95982},
abstract = {Fibromyalgia (FM) is a chronic syndrome of unknown etiology, although many studies point
to inflammation, oxidative stress, and altered mitochondrial metabolism as some of the cornerstones
of this disease. Despite its socioeconomic importance and due to the difficulties in diagnosis, there
are no effective treatments. However, the use of non-drug treatments is increasingly becoming
a recommended strategy. In this context, the effects of supplementation of FM patients with an
olive (poly)phenol, vitamin C, and vitamin B preparation were investigated in this work, analyzing
complete blood count, biochemical, lipid, and coagulation profiles, and inflammation and oxidation
status in blood samples. To gain a better understanding of the molecular mechanisms and pathways
involved in the etiology of FM, a proteomic study was also performed to investigate the mechanisms
of action of the supplement. Our results show that the nutraceutical lowers the lipid profile, namely
cholesterol, and improves the oxidative status of patients as well as their quality of life, suggesting
that this product could be beneficial in the co-treatment of FM. ClinicalTrials.gov (ID: NCT06348537)},
organization = {Solvitae Medical, S.L.},
organization = {University of Jaen for the provision of advisory technical-scientist services (grant number 4147)},
publisher = {MDPI},
keywords = {fibromyalgia},
keywords = {olive oil},
keywords = {proteomics},
title = {Nutraceutical Supplementation as a Potential Non-Drug Treatment for Fibromyalgia: Effects on Lipid Profile, Oxidative Status, and Quality of Life},
doi = {10.3390/ijms25189935},
author = {De la Cruz Cazorla, Salvador and Blanco, Santos and Rus Martínez, María del Alma and Molina Ortega, Francisco Javier and Ocaña, Esther and Hernández, Raquel and Visioli, Francesco and Del Moral, María Luisa},
}