@misc{10481/95899,
year = {2017},
month = {8},
url = {https://hdl.handle.net/10481/95899},
abstract = {Interactions between the hypothalamus and non-homeostatic regions may contribute to explain the difficulty to lose weight in obesity, an assumption never tested in human longitudinal studies. We investigated whether the functional connectivity between the medial and lateral hypothalamus (MH and LH) and corticostriatal regions differs between individuals with excess weight (n = 42) and normal weight (n = 39) using a seed-based resting-state approach. In addition, we examined the longitudinal association between functional connectivity and weight loss in a 3-month follow-up diet. Results showed that participants with excess weight had increased connectivity between the MH and the striatum and subgenual anterior cingulate cortex, and decreased connectivity with the middle frontal gyrus, and the bed nucleus of the stria terminalis (BNST), as well as a decreased connectivity between the LH and the cerebellum. Decreased connectivity between the MH and the posterior part of the BNST, and between the LH and the cerebellar cortex, predicted a greater percentage of weight loss. Functional connectivity measures explained 36% of the 3-month weight change among individuals with excess weight. We conclude that altered functional connectivity between homeostatic-hypothalamic regions and non-homeostatic corticostriatal and cerebellar regions is linked to obesity and difficulty to lose weight.},
organization = {Project Grant NEUROCOBE (PI-HUM-6635) from the Andalusian Council of Innovation, Science and Industry},
organization = {The Ian Potter Foundation Medical Project Grant},
organization = {Project Grant PI16/00889 from the Spanish Ministry of Economy and Competitiveness},
organization = {FEDER funds -a way to build Europe-},
organization = {‘Miguel Servet’ contract (CPII16/00048) and ‘Sara Borrell’ postdoctoral fellowship (CD14/00246) from the Carlos III Health Institute},
organization = {FPU predoctoral fellowship (FPU13/00669) from the Spanish Ministry of Education, Culture and Sport},
publisher = {Springer Nature},
title = {Altered cross-talk between the hypothalamus and nonhomeostatic regions linked to obesity and difficulty to lose weight},
doi = {10.1038/s41598-017-09874-y},
author = {Contreras Rodríguez, Oren and Vilar López, Raquel and Andrews, Zane B. and Navas, Juan F. and Soriano-Mas, Carles and Verdejo García, Antonio Javier},
}