@misc{10481/95599,
year = {2016},
month = {2},
url = {https://hdl.handle.net/10481/95599},
abstract = {Objective
To assess the effects of one intra-articular corticosteroid injection two weeks prior to an
exercise-based intervention program for reducing pain sensitivity in patients with knee osteoarthritis
(OA).
Design
Randomized, masked, parallel, placebo-controlled trial involving 100 participants with clinical
and radiographic knee OA that were randomized to one intra-articular injection on the
knee with either 1 ml of 40 mg/ml methylprednisolone (corticosteroid) dissolved in 4 ml lidocaine
(10 mg/ml) or 1 ml isotonic saline (placebo) mixed with 4 ml lidocaine (10 mg/ml). Two
weeks after the injections all participants undertook a 12-week supervised exercise program.
Main outcomes were changes from baseline in pressure-pain sensitivity (pressurepain
threshold [PPT] and temporal summation [TS]) assessed using cuff pressure algometry
on the calf. These were exploratory outcomes from a randomized controlled trial.
Results
A total of 100 patients were randomized to receive either corticosteroid (n = 50) or placebo
(n = 50); 45 and 44, respectively, completed the trial. Four participants had missing values
for PPT and one for TS at baseline; thus modified intention-to-treat populations were analyzed.
The mean group difference in changes from baseline at week 14 was 0.6 kPa (95%
CI: -1.7 to 2.8; P = 0.626) for PPT and 384 mm×sec (95% CI: -2980 to 3750; P = 0.821) for
TS.
Conclusions
These results suggest that adding intra-articular corticosteroid injection 2 weeks prior to an
exercise program does not provide additional benefits compared to placebo in reducing
pain sensitivity in patients with knee OA.},
organization = {Grant 10-093704 from the Danish Council for Independent
Research, Medical Science and by the Oak
Foundation, Association of Danish Physiotherapists,
Lundbeck Foundation, and Capital Region of
Denmark},
organization = {Spanish
Ministry of Education, Culture and Sport (FPU12/00963)},
publisher = {Soriano-Maldonado A, Klokker L, Bartholdy C, Bandak E, Ellegaard K, Bliddal H, et al. (2016) Intra-Articular Corticosteroids in Addition to Exercise for Reducing Pain Sensitivity in Knee Osteoarthritis: Exploratory Outcome from a Randomized Controlled Trial. PLoS ONE 11(2): e0149168. doi:10.1371/journal.pone.0149168},
title = {Intra-Articular Corticosteroids in Addition to Exercise for Reducing Pain Sensitivity in Knee Osteoarthritis: Exploratory Outcome from a Randomized Controlled Trial},
doi = {10.1371/journal.pone.0149168},
author = {Soriano-Maldonado, Alberto and Klokker, Louise and Bartholdy, Cecilie and Bandak, Elisabeth and Ellegaard, Karen and Bliddal, Henning and Henriksen, Marius},
}