@misc{10481/95588,
year = {2016},
month = {1},
url = {https://hdl.handle.net/10481/95588},
abstract = {In this paper we analyze the interplay between the subthreshold oscillations of a single neuron
conductance-based model and the short-term plasticity of a dynamic synapse with a
depressing mechanism. In previous research, the computational properties of subthreshold
oscillations and dynamic synapses have been studied separately. Our results show that
dynamic synapses can influence different aspects of the dynamics of neuronal subthreshold
oscillations. Factors such as maximum hyperpolarization level, oscillation amplitude
and frequency or the resulting firing threshold are modulated by synaptic depression, which
can even make subthreshold oscillations disappear. This influence reshapes the postsynaptic
neuron’s resonant properties arising from subthreshold oscillations and leads to specific
input/output relations. We also study the neuron’s response to another simultaneous
input in the context of this modulation, and show a distinct contextual processing as a function
of the depression, in particular for detection of signals through weak synapses. Intrinsic
oscillations dynamics can be combined with the characteristic time scale of the modulatory
input received by a dynamic synapse to build cost-effective cell/channel-specific information
discrimination mechanisms, beyond simple resonances. In this regard, we discuss the functional
implications of synaptic depression modulation on intrinsic subthreshold dynamics.},
organization = {MINECO
TIN2012-30883 and FIS2013-43201-P},
publisher = {Plos One},
title = {Interplay between Subthreshold Oscillations and Depressing Synapses in Single Neurons},
doi = {10.1371/journal.pone.0145830},
author = {Latorre, Roberto and Torres Agudo, Joaquín and Varona, Pablo},
}