@misc{10481/95548,
year = {2015},
month = {11},
url = {https://hdl.handle.net/10481/95548},
abstract = {Objective
Diabetes during gestation is one of the most common pregnancy complications associated
with adverse health effects for the mother and the child. Maternal diabetes has been proposed
to negatively affect the cognitive abilities of the child, but experimental research
assessing its impact is conflicting. The main aim of our study was to compare the cognitive
function in children of diabetic and healthy pregnant women.
Methods
A systematic review and meta-analysis was conducted through a literature search using different
electronic databases from the index date to January 31, 2015. We included studies
that assessed the cognitive abilities in children (up to 14 years) of diabetic and non-diabetic
mothers using standardized and validated neuropsychological tests.
Results
Of 7,698 references reviewed, 12 studies involving 6,140 infants met our inclusion criteria
and contributed to meta-analysis. A random effect model was used to compute the standardized
mean differences and 95% confidence interval (CI) were calculated. Infants (1–2
years) of diabetic mothers had significantly lower scores of mental and psychomotor development
compared to control infants. The effect size for mental development was -0.41
(95% CI -0.59, -0.24; p<0.0001) and for psychomotor development was -0.31 (95% CI
-0.55, -0.07; p = 0.0125) with non-significant heterogeneity. Diabetes during pregnancy
could be associated with decreased intelligence quotient scores in school-age children,
although studies showed significant heterogeneity.
Conclusion
The association between maternal diabetes and deleterious effects on mental/psychomotor
development and overall intellectual function in the offspring must be taken with caution.
Results are based on observational cohorts and a direct causal influence of intrauterine
hyperglycemia remains uncertain. Therefore, more trials that include larger populations are
warranted to elucidate whether gestational diabetes mellitus (GDM) has a negative impact
on offspring central nervous system (CNS).},
publisher = {Plos One},
title = {Maternal Diabetes and Cognitive Performance in the Offspring: A Systematic Review and Meta-Analysis},
doi = {10.1371/journal.pone.0142583},
author = {Camprubi Robles, Maria and Campoy Folgoso, Cristina and Garcia Fernandez, Llenalia and López Pedrosa, José M. and Rueda, Ricardo and Martin, Maria J.},
}